Cosmetic peptides
Definition
Cosmetic peptides are one of the active components of modern day cosmetic preparation. A cosmetic product has the property of activating the melanogenesis and being an anti-inflammatory and acting more efficiently. Acetyl hexapeptide-3, Palmitoyl Pentapeptide , Palmitoyl hexapeptide , Palmitoyl Tetrapeptide-3 , PAL-GHK are some of the common Cosmetic peptides.
Discovery
Acetyl Hexapeptide-3, a synthetic anti-aging cosmetic ingredient derived from natural proteins1. The palmitoyl in palmitoyl pentapeptide, or pal-KTTKS, is derived from interferon-alpha 2. Palmitoyl Tetrapeptide-3 is a synthetic peptide that is a fragment of immunoglobulin G 3. Palmitoyl Tetrapeptide-3 was discovered through research to learn how to suppress the body's production of interleukins (IL6).
Structural Characteristics
Palmitoyl pentapeptide is a derivative of the pro-collagen I pentapeptide, a chain of five amino acid fragments lysine-threonine-threonine-lysine-serine also known as the KTTKS peptide4. Palmitoyl Hexapeptide-14 is a short bioactive peptide modified with palmitoyl.
The sequence of palmitoyl hexapeptide is Pal-Val-Gly-Val-Ala-Pro-Gly-OH.
The sequence of Palmitoyl Tetrapeptide-3 is Pal-Gly-Gln-Pro-Arg-OH.
The sequence of Acetyl Hexapeptide-3 is Ac-Glu-Glu-Met-Gln-Arg-Arg-OH
Mode of Action
Acetyl Hexapeptide-3 acts as a wrinkle preventative is by competing with SNAP-25 for a position in the SNARE complex. This destabilizes the SNARE complex, preventing the vesicle from releasing neurotransmitters efficiently, and therefore attenuating muscle contraction. This causes a reduction in facial muscle contraction, which is believed to help prevent the long-term formation of lines and wrinkles. The second way that Acetyl Hexapeptide-3 acts as a wrinkle preventative is by reducing the release of catecholamines (the overproduction of which is known to induce the formation of wrinkles and fine lines in the skin), specifically adrenaline and noradrenaline5.
Palmitoyl Pentapeptide creates a response in the dermis of the skin that stimulates collagen and elastin fibroblasts, developing fibronectin (FN) and glycosaminoglycans (GAG).
Palmitoyl tetrapeptide is believed to work by reducing the production of interleukin-6 (IL-6) by the the key skin cells, keratinocytes and fibroblasts. IL-6 is a molecule that promotes inflammation, which, in turn, leads to faster degradation of the skin matrix and thus contributes to the development of wrinkles and loss of skin firmness and elasticity. By reducing the levels of IL-6 and possibly other inflammation mediators, palmitoyl tetrapeptide is thought to slow down the degradation of the skin matrix and may also stimulate its replenishment5.
Functions
Acetyl Hexapeptide 3 temporarily limits the overproduction and release of neurotransmitters that initiate and control the intensity of facial muscle contractions. At a 10% concentration, Acetyl Hexapeptide 3 has been shown to reduce the depth of wrinkles up to 30% after 30 days of trial use. Argireline is a peptide (acetyl hexapeptide-3) that inhibits SNARE complex formation and catecholamine release, resulting in the reduction of the degree of existing facial wrinkles6.
Palmitoyl Pentapeptide stimulates production of dermal matrix components (in particular collagen) which is believed to be involved in its skin activity. Pal-KTTKS is also reported to be involoved in thickening of epidermis and reduction in aging skin's excess production of dermal glycosaminoglycan (GAG)7.
References
1.Book: Cosmetic Dermatology. By Graf J. Chapter 2: Anti-aging skin care ingredient technologies. Springer Berlin Heidelberg, 17-28.
2.Foldvari M, Attah-Poku S, Hu J (1998). Palmitoyl derivatives of interferon alpha: potent for cutaneous delivery. J Pharm Sci., 87:1203-1208.
3.Patent: Bellin HT Beatrice DB. "A topically applied composition or cream for treatment of the skin". U. S. Patent 7,544,375 June 2009.
4.Bissett D (2009). Common cosmeceuticals. Clin Dermatol., 27(5):435-445.
5.Zhang L, Falla TJ (2009). Cosmeceuticals and peptides. Clin Dermatol., 27(5):485-494.
6.Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernández-Ballester G, Ponsati B, Gutierrez L, Pérez-Payá E, Ferrer-Montiel A (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci., 24(5):303-310.
7.Book: Textbook of Aging Skin By Donald L. Bissett DL, Johnson MB. Springer Berlin Heidelberg. 5(31):1069-1078.
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Cosmetic peptides are one of the active components of modern day cosmetic preparation. A cosmetic product has the property of activating the melanogenesis and being an anti-inflammatory and acting more efficiently. Acetyl hexapeptide-3, Palmitoyl Pentapeptide , Palmitoyl hexapeptide , Palmitoyl Tetrapeptide-3 , PAL-GHK are some of the common Cosmetic peptides.
Discovery
Acetyl Hexapeptide-3, a synthetic anti-aging cosmetic ingredient derived from natural proteins1. The palmitoyl in palmitoyl pentapeptide, or pal-KTTKS, is derived from interferon-alpha 2. Palmitoyl Tetrapeptide-3 is a synthetic peptide that is a fragment of immunoglobulin G 3. Palmitoyl Tetrapeptide-3 was discovered through research to learn how to suppress the body's production of interleukins (IL6).
Structural Characteristics
Palmitoyl pentapeptide is a derivative of the pro-collagen I pentapeptide, a chain of five amino acid fragments lysine-threonine-threonine-lysine-serine also known as the KTTKS peptide4. Palmitoyl Hexapeptide-14 is a short bioactive peptide modified with palmitoyl.
The sequence of palmitoyl hexapeptide is Pal-Val-Gly-Val-Ala-Pro-Gly-OH.
The sequence of Palmitoyl Tetrapeptide-3 is Pal-Gly-Gln-Pro-Arg-OH.
The sequence of Acetyl Hexapeptide-3 is Ac-Glu-Glu-Met-Gln-Arg-Arg-OH
Mode of Action
Acetyl Hexapeptide-3 acts as a wrinkle preventative is by competing with SNAP-25 for a position in the SNARE complex. This destabilizes the SNARE complex, preventing the vesicle from releasing neurotransmitters efficiently, and therefore attenuating muscle contraction. This causes a reduction in facial muscle contraction, which is believed to help prevent the long-term formation of lines and wrinkles. The second way that Acetyl Hexapeptide-3 acts as a wrinkle preventative is by reducing the release of catecholamines (the overproduction of which is known to induce the formation of wrinkles and fine lines in the skin), specifically adrenaline and noradrenaline5.
Palmitoyl Pentapeptide creates a response in the dermis of the skin that stimulates collagen and elastin fibroblasts, developing fibronectin (FN) and glycosaminoglycans (GAG).
Palmitoyl tetrapeptide is believed to work by reducing the production of interleukin-6 (IL-6) by the the key skin cells, keratinocytes and fibroblasts. IL-6 is a molecule that promotes inflammation, which, in turn, leads to faster degradation of the skin matrix and thus contributes to the development of wrinkles and loss of skin firmness and elasticity. By reducing the levels of IL-6 and possibly other inflammation mediators, palmitoyl tetrapeptide is thought to slow down the degradation of the skin matrix and may also stimulate its replenishment5.
Functions
Acetyl Hexapeptide 3 temporarily limits the overproduction and release of neurotransmitters that initiate and control the intensity of facial muscle contractions. At a 10% concentration, Acetyl Hexapeptide 3 has been shown to reduce the depth of wrinkles up to 30% after 30 days of trial use. Argireline is a peptide (acetyl hexapeptide-3) that inhibits SNARE complex formation and catecholamine release, resulting in the reduction of the degree of existing facial wrinkles6.
Palmitoyl Pentapeptide stimulates production of dermal matrix components (in particular collagen) which is believed to be involved in its skin activity. Pal-KTTKS is also reported to be involoved in thickening of epidermis and reduction in aging skin's excess production of dermal glycosaminoglycan (GAG)7.
References
1.Book: Cosmetic Dermatology. By Graf J. Chapter 2: Anti-aging skin care ingredient technologies. Springer Berlin Heidelberg, 17-28.
2.Foldvari M, Attah-Poku S, Hu J (1998). Palmitoyl derivatives of interferon alpha: potent for cutaneous delivery. J Pharm Sci., 87:1203-1208.
3.Patent: Bellin HT Beatrice DB. "A topically applied composition or cream for treatment of the skin". U. S. Patent 7,544,375 June 2009.
4.Bissett D (2009). Common cosmeceuticals. Clin Dermatol., 27(5):435-445.
5.Zhang L, Falla TJ (2009). Cosmeceuticals and peptides. Clin Dermatol., 27(5):485-494.
6.Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernández-Ballester G, Ponsati B, Gutierrez L, Pérez-Payá E, Ferrer-Montiel A (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci., 24(5):303-310.
7.Book: Textbook of Aging Skin By Donald L. Bissett DL, Johnson MB. Springer Berlin Heidelberg. 5(31):1069-1078.
Please visit our Blog on Blogspot Bio-Synthesis
BIO-SYNTHESIS
BIO-SYNTHESIS, INC., is a leading life science products company with over 20 years of experience in the design and synthesis of Custom Peptide, small molecules and reagents for small scale research and bulk pharmaceutical trials. Using state of the art technology in our well-equipped laboratories.
Please visit our Blog on Blogspot Bio-Synthesis
Please visit our Blog on Blogspot Bio-Synthesis
Custom Peptides
Bio-Synthesis, founded in 1984, is a U.S. based company whose primary emphasis is providing high quality custom products such as custom oligonucleotide, custom peptides, custom antibody, and services for life science research, diagnostics, and therapeutic applications. Our integrated manufacturing programs enable a seamless transition from the inception of an idea through product launch by providing our client with a comprehensive portfolio of services that span across genomic, proteomic, and cell biology.
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About BSI
"The use of state-of-the art technology has allowed Bio-Synthesis, Inc. to rapidly gain recognition for its manufacturing quality & dependability of delivery."
Founded in 1984, Bio-Synthesis, Inc. was first known as OCS Laboratories. It was the first producer of commercially available synthetic DNA and, in 1985, became a producer of synthetic peptides. In 1989, OCS incorporated as Bio-Synthesis, Inc. and moved its laboratories to Lewisville, Texas. Today, BSI occupies 10,000 square feet of modern laboratory space (completed in 1995) located 20 miles from downtown Dallas and 10 miles from D/FW airport. Among the surrounding academic institutions are: University of Texas Southwestern Medical School (12 miles), University of North Texas (10 miles), and University of North Texas Health Science Center (25 miles). These universities provide excellent library resources. Since its inception, BSI has steadily expanded its product lines and services to meet the growing needs of the molecular biology community. It has maintained its position as an aggressive, innovative company in a highly competitive marketplace without sacrificing quality. In the beginning, our primary emphasis was on synthesizing high quality DNA primers and linkers, which were the initial uses of oligos. Today, newer technologies, such as gene construction, PCR, mutagenesis, combinatorial libraries, dye/adduct labeling, DNA microarrays, peptide-nucleic acid chimeras, etc. have challenged the molecular biology field. In response, BSI has branched into several related areas including DNA paternity testing, DNA HLA typing, PNA synthesis, genomic sequencing, fluorescence-based genotyping, custom organic synthesis and other molecular biology based applications.
The Research and Development Division comprises a number of Ph.D. and M.D. professionals with backgrounds in molecular biology, immunology, nucleic acids, peptide synthesis, general organic chemistry, and automated amino acid sequencing. The Molecular Biology Division is set up to handle most modern experimental procedures; the Immunology Division specializes in immunodiagnostic-based reagents.
Not only has BSI continued to provide quality DNA products and services for the research community, but it has also become a world leader in providing custom peptide products and services. Using state-of-the-art solid phase peptide chemistries, BSI provides high quality custom peptides, performs carrier conjugations, antipeptide antibody production, antigenic peptide design, synthesis of long and/or modified peptides, MALDI TOF analysis, contract research, consultation services and more.
Biomedical researchers worldwide in universities, biotech companies, private clinics, and government agencies use products from Bio-Synthesis, Inc. in studies ranging from PCR diagnostics to cancer research and the Human Genome Project. Contact us to discover how BSI can customize products/services to suit your research requirements.
For more detail please visit our About Us
Please Contact Us :
Address: 612 E. Main street
City: Lewisville
State: Texas
Country: USA
Postal Code: 75057
Phone Number: 972-420-8505
Founded in 1984, Bio-Synthesis, Inc. was first known as OCS Laboratories. It was the first producer of commercially available synthetic DNA and, in 1985, became a producer of synthetic peptides. In 1989, OCS incorporated as Bio-Synthesis, Inc. and moved its laboratories to Lewisville, Texas. Today, BSI occupies 10,000 square feet of modern laboratory space (completed in 1995) located 20 miles from downtown Dallas and 10 miles from D/FW airport. Among the surrounding academic institutions are: University of Texas Southwestern Medical School (12 miles), University of North Texas (10 miles), and University of North Texas Health Science Center (25 miles). These universities provide excellent library resources. Since its inception, BSI has steadily expanded its product lines and services to meet the growing needs of the molecular biology community. It has maintained its position as an aggressive, innovative company in a highly competitive marketplace without sacrificing quality. In the beginning, our primary emphasis was on synthesizing high quality DNA primers and linkers, which were the initial uses of oligos. Today, newer technologies, such as gene construction, PCR, mutagenesis, combinatorial libraries, dye/adduct labeling, DNA microarrays, peptide-nucleic acid chimeras, etc. have challenged the molecular biology field. In response, BSI has branched into several related areas including DNA paternity testing, DNA HLA typing, PNA synthesis, genomic sequencing, fluorescence-based genotyping, custom organic synthesis and other molecular biology based applications.
The Research and Development Division comprises a number of Ph.D. and M.D. professionals with backgrounds in molecular biology, immunology, nucleic acids, peptide synthesis, general organic chemistry, and automated amino acid sequencing. The Molecular Biology Division is set up to handle most modern experimental procedures; the Immunology Division specializes in immunodiagnostic-based reagents.
Not only has BSI continued to provide quality DNA products and services for the research community, but it has also become a world leader in providing custom peptide products and services. Using state-of-the-art solid phase peptide chemistries, BSI provides high quality custom peptides, performs carrier conjugations, antipeptide antibody production, antigenic peptide design, synthesis of long and/or modified peptides, MALDI TOF analysis, contract research, consultation services and more.
Biomedical researchers worldwide in universities, biotech companies, private clinics, and government agencies use products from Bio-Synthesis, Inc. in studies ranging from PCR diagnostics to cancer research and the Human Genome Project. Contact us to discover how BSI can customize products/services to suit your research requirements.
For more detail please visit our About Us
Please Contact Us :
Address: 612 E. Main street
City: Lewisville
State: Texas
Country: USA
Postal Code: 75057
Phone Number: 972-420-8505
New My Lenses
Custom Antibody
As a leading supplier of genomic and proteomic research products, BSI is able to offer its customers integrated solutions for custom DNA synthesis, custom RNA synthesis, custom polyclonal antibody production, custom peptide synthesis, molecular diagnostic detection kits, DNA Real-Time PCR products, DNA microarray services and a wide range of custom DNA-based diagnostic kits and consumables.
The proteomic division is experienced in the design of peptides, both for antibody production and bioactive peptide synthesis, e.g cosmetic peptides. While the custom peptide synthesis division has the ability to produce thousands of modified or non-modified peptides per day for research applications, BSI also provides diagnostic/therapeutic GMP custom peptide production. Synthesis of custom peptides results in quantities ranging from milligrams to multi-kilograms. The staff in the custom antibody division provide expert support in the selection of peptide antigens for target antibody production and offer convenient custom-bundled packages with a wide range of host animals. In addition, peptide, antibody and protein arrays are also amongst its expertise.
BSI is a U.S. based company whose primary emphasis is on the synthesis of high quality custom products for a variety of applications and a full-service contract manufacturing organization (CMO) delivering research, development and production services for cGMP clinical batch manufacturing.
BIO-SYNTHESIS
BIO-SYNTHESIS, INC., is a leading life science products company with over 20 years of experience in the design and synthesis of Custom Peptide, small molecules and reagents for small scale research and bulk pharmaceutical trials. Using state of the art technology in our well-equipped laboratories.
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