Prison Break is an American serial drama television series that premiered on the Fox Broadcasting Company on August 29, 2005. The story revolves around a man who was sentenced to death for a crime he did not commit and his brother's elaborate plan to help him escape his death sentence. Created by Paul Scheuring, the show is produced by Adelstein-Parouse Productions in association with Original Television and 20th Century Fox Television. The current executive producers are Paul Scheuring, Matt Olmstead, Kevin Hooks, Marty Adelstein, Dawn Parouse, Neal Moritz and Brett Ratner. Its theme music is composed by Ramin Djawadi, and was nominated for a Primetime Emmy Award in 2006.

The show is currently in its third season. The uniqueness of Prison Break is attributed to its serialized story structure, a similar format used by Lost and 24, and to its setting, as very few television series were primarily set and filmed in a prison.Its success and recognition as a prison drama revived interest in the genre.
In 2008 a spin-off of the show will start airing on FOX Network that will follow female prisoners called Prison Break: Cherry Hill.

The original concept of Prison Break-a man deliberately getting himself sent to prison in order to help someone else escape-was suggested to Paul Scheuring by producer Dawn Parouse, who wanted to produce an action-oriented series. Although Scheuring thought it was a good idea, he was initially stumped as to why someone would embark on such a mission or how he could develop it into a viable television show. He came up with the story of the wrongfully accused brother, and began working on the plot outline and devising the characters. In 2003, he pitched the idea to the Fox Broadcasting Company but was turned down as Fox felt nervous about the long-term possibilities of such a series. He subsequently showed the concept to other channels but was also turned down as it was thought to be more suited for a film project than a television series. Prison Break was later considered as a possible 14-part miniseries, which drew the interest of Steven Spielberg before his departure due to his involvement with War of the Worlds. Thus, the miniseries never materialized. Following the huge popularity of serialized prime time television series such as Lost and 24, the Fox Network had a change of heart and backed the production in 2004. The pilot episode was filmed a year after Scheuring wrote the script and five months later, the show was picked up as a series.