L-trans-epoxysuccinyl peptide
Ranked #97,321 in Healthy Living, #977,619 overall
L-trans-Epoxysuccinyl Peptides
L-trans-epoxysuccinyl peptide is a potent inhibitor specific for cathepsin B in vitro (IC50= 2.24 nM for rat liver cathepsin B) and in vivo. L-trans-epoxysuccinyl-leucylamido (4-guanidino)butane (E-64) rapidly in activates the cysteine proteinases cathepsins B, H and L and papain.
Discovery
In 1982, Barrette et al., identified a new class of compounds that show promise of acting as class-specific inhibitors for the cysteine proteinases, are the L-trans-epoxysuccinylpeptides related to the compound E-64 [L-trans-epoxysuccinyl- L-leucylamido(4-guanidino)butanel, isolated from cultures of Aspergillus japonicus 1, 2.
Structural Characteristics
[L-3-trans-Carboxyoxiran-2-Carbonyl]-L-Leu-Agmatin][N-(trans-epoxysuccinyl)-L-leucine 4-guanidinobutylamide] has a structure C15H27N5O5, 0.5 H2O and molecular weight of 357.41 kDa 3.
Please visit our Blog on Blogspot Bio-Synthesis
Custom Peptides
Bio-Synthesis, founded in 1984, is a U.S. based company whose primary emphasis is providing high quality custom products such as custom oligonucleotide, custom peptides, custom antibody, and services for life science research, diagnostics, and therapeutic applications. Our integrated manufacturing programs enable a seamless transition from the inception of an idea through product launch by providing our client with a comprehensive portfolio of services that span across genomic, proteomic, and cell biology.
BIO-SYNTHESIS Lenses
New Text with BIG Picture
Custom Antibody

As a leading supplier of genomic and proteomic research products, BSI is able to offer its customers integrated solutions for custom DNA synthesis, custom RNA synthesis, custom polyclonal antibody production, custom peptide synthesis, molecular diagnostic detection kits, DNA Real-Time PCR products, DNA microarray services and a wide range of custom DNA-based diagnostic kits and consumables.
The proteomic division is experienced in the design of peptides, both for antibody production and bioactive peptide synthesis, e.g cosmetic peptides. While the custom peptide synthesis division has the ability to produce thousands of modified or non-modified peptides per day for research applications, BSI also provides diagnostic/therapeutic GMP custom peptide production. Synthesis of custom peptides results in quantities ranging from milligrams to multi-kilograms. The staff in the custom antibody division provide expert support in the selection of peptide antigens for target antibody production and offer convenient custom-bundled packages with a wide range of host animals. In addition, peptide, antibody and protein arrays are also amongst its expertise.
BSI is a U.S. based company whose primary emphasis is on the synthesis of high quality custom products for a variety of applications and a full-service contract manufacturing organization (CMO) delivering research, development and production services for cGMP clinical batch manufacturing.
New RSS: Add your blog
Make your own RSS module. 1. Add to your lens. 2. Paste any RSS (xml) link location into the module. 3. Select how often you want it to update. 4. Boom! Customized feeds for your topic.New My Lenses
New Text with BIG Picture
BIO-SYNTHESIS
Fetching RSS feed... please stand byby Bio-Synthesis
BIO-SYNTHESIS, INC., is a leading life science products company with over 20 years of experience in the design and synthesis of Custom Peptide, small... more »
- 1 featured lens
- Winner of 5 trophies!
- Top lens » Cosmetic Peptides