L-trans-epoxysuccinyl peptide

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L-trans-Epoxysuccinyl Peptides

Definition
L-trans-epoxysuccinyl peptide is a potent inhibitor specific for cathepsin B in vitro (IC50= 2.24 nM for rat liver cathepsin B) and in vivo. L-trans-epoxysuccinyl-leucylamido (4-guanidino)butane (E-64) rapidly in activates the cysteine proteinases cathepsins B, H and L and papain.

Discovery
In 1982, Barrette et al., identified a new class of compounds that show promise of acting as class-specific inhibitors for the cysteine proteinases, are the L-trans-epoxysuccinylpeptides related to the compound E-64 [L-trans-epoxysuccinyl- L-leucylamido(4-guanidino)butanel, isolated from cultures of Aspergillus japonicus 1, 2.

Structural Characteristics
[L-3-trans-Carboxyoxiran-2-Carbonyl]-L-Leu-Agmatin][N-(trans-epoxysuccinyl)-L-leucine 4-guanidinobutylamide] has a structure C15H27N5O5, 0.5 H2O and molecular weight of 357.41 kDa 3.

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As a leading supplier of genomic and proteomic research products, BSI is able to offer its customers integrated solutions for custom DNA synthesis, custom RNA synthesis, custom polyclonal antibody production, custom peptide synthesis, molecular diagnostic detection kits, DNA Real-Time PCR products, DNA microarray services and a wide range of custom DNA-based diagnostic kits and consumables.

The proteomic division is experienced in the design of peptides, both for antibody production and bioactive peptide synthesis, e.g cosmetic peptides. While the custom peptide synthesis division has the ability to produce thousands of modified or non-modified peptides per day for research applications, BSI also provides diagnostic/therapeutic GMP custom peptide production. Synthesis of custom peptides results in quantities ranging from milligrams to multi-kilograms. The staff in the custom antibody division provide expert support in the selection of peptide antigens for target antibody production and offer convenient custom-bundled packages with a wide range of host animals. In addition, peptide, antibody and protein arrays are also amongst its expertise.

BSI is a U.S. based company whose primary emphasis is on the synthesis of high quality custom products for a variety of applications and a full-service contract manufacturing organization (CMO) delivering research, development and production services for cGMP clinical batch manufacturing.

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BIO-SYNTHESIS

BIO-SYNTHESIS, INC., is a leading life science products company with over 20 years of experience in the design and synthesis of Custom Peptide, small molecules and reagents for small scale research and bulk pharmaceutical trials. Using state of the art technology in our well-equipped laboratories.
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