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Just the Facts: NIACIN

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MEDICAL WARNING

 

THERE IS RISK OF TOXICITY IN TAKING LARGE DOSAGES OF NIACIN! ALWAYS CONSULT WITH A KNOWLEDGEABLE HEALTH CARE PROVIDER BEFORE STARTING HIGH DOSES OF NIACIN.

 

 

Photo from www.fotosearch.com/ARP105/poison

 

Overview 

Niacin, vitamin B3, Pantothenic acid: These three names are the same substance, a water-soluble vitamin found in all cells in the body. Niacin is necessary for cellular metabolism, growth, and reproduction.

Inositol hexaniacinate: Another closely related drug that is being investigated as a safer approach to niacin. In the tests run so far, inositol hexaniacinate has shown great promise as a drug that can provide similar results and be free of the side effects of niacin. Further research may show that it will provide help for other medical conditions.

Pellagra: Caused by a severe lack of niacin in a diet. Common symptoms of pellagra involve the skin (rash), digestive system (a bright red tongue, vomiting, and diarrhea), and the nervous system (headache, apathy, fatigue, depression, disorientation, and memory loss). Physicians in areas of the world where people eat foods lacking usable niacin commonly refer the pellagra stages as the four D's-dermatitis, diarrhea, dementia, and death.

Tryptophan: One of 20 essential amino acids found in vertebrate proteins. Common foods that have large amounts of tryptophan are chocolate, oats, bananas, and milk; it is the precursor of serotonin and niacin.

Photo from www.worldofmolecules.com/supplements/niacin.htm

Functions of Niacin in the Body 

1. Assists in the functioning of the digestive system, skin, and nerves. It is also important for the conversion of food to energy.

2. Helps to convert carbohydrates into glucose (sugar), which is "burned" to produce energy.

3. Contributes in the breakdown of fats and protein.

4. Helps in ridding the body of toxic and harmful chemicals.

5. Makes various sex and stress-related hormones in the adrenal glands and other parts of the body.

6. Improve circulation and reduce cholesterol levels in the blood

7. Human body is able to convert tryptophan, an amino acid, into niacin.

Medical Uses 

The following are medical uses of niacin. I have added some hopes for the future as this drug seems to be comparatively safe and could be a "miracle" drug. However, there is still much to be learned.

High Cholesterol

1. Lowers elevated LDL ("bad") cholesterol.

2. Increases HDL ("good") cholesterol

3. Lowers triglyceride (fat) levels in the blood.

Atherosclerosis

1. Used to prevent development of atherosclerosis (plaque along the blood vessels that can cause blockage)

2. Reduces recurrent complications such as heart attack and peripheral vascular disease (atherosclerosis of the blood vessels in the legs that can cause pain with walking, called intermittent claudication) in those with the condition.

3. The combination of niacin and a cholesterol-lowering drug may dramatically slow the progression of heart disease, reducing risk of heart attack, and even death.

Diabetes

Studies are currently being run to study the uses that niacin might be to persons suffering from diabetes. Some research points to beneficial results, but much more research will be necessary before physicians will understand how to use this drug.

Osteoarthritis

There has been no definitive research showing that the arthritis disease can be helped by niacin. However, the research is continuing with hopes that it can be used for the following:

1. Niacinamide may improve arthritis symptoms.

2. Niacinamide may aid cartilage repair (damage to joint cartilage causes arthritis).

Cataracts

There is some hope that the B complex vitamins (which includes niacin, vitamin B3) could be effective in preventing cataracts (damage to the lens of the eye which can lead to cloudy vision).

Burns

Although it is unclear which micronutrients are most beneficial for people with burns, many studies suggest that a multivitamin including the B complex vitamins may aid in the recovery process.

Other

Niacin skin salves may be used in future years as anti-aging agents, for treatment of acne, and even for prevention of skin cancer.

Food Sources 

organ meats, especially liver, beef kidney, lean meats, pork, and veal; Swiss cheese and most dairy products; poultry products eggs, and turkey; fish, especially swordfish, tuna, and salmon; rice bran and brown rice; wheat/wheat germ and brewer's yeast; nuts especially peanuts and sunflower seeds; leafy green vegetables, potatoes, green peas, lima beans, legumes, parsley, broccoli, and beets; avocados, dates, and figs; mushrooms; enriched breads and cereals

Trusted Links 

There are several hundred sites on the Internet concerning Niacin. Most of them are oriented toward selling something. That in itself doesn't mean that the information a site gives out is wrong; it just means the information might be slanted and we want straight information. There is an active research community studying niacin and the sites below are the most trusted sites to give you the best information. Read anything you want but trust these cites.
University of Maryland Medical Center
PDRhealth
Merck Manuals
Linus Pauling Institute
Northwestern University

Niacin News 

The following link has continuous information on virtually all niacin-related news. This information is quite complete and will include some inaccuracies, but you can get a better understanding by reading the articles and stories.
topix.net

New Amazon Standard 

Eat, Drink, and Be Healthy: The Harvard Medical School Guide to Healthy Eating

This is an excellent overall book on how to eat to stay healthy.

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Herbal Drugstore

There's more information here than one person could ever use.

Amazon Price: $11.37 (as of 11/22/2008) Buy Now

Niacin - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

The bible for those studying niacin.

Amazon Price: $28.95 (as of 11/22/2008) Buy Now

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Forrie

About Forrie

Canton OH: Born; learned to read->Anderson IN: Young thinking, Nature->Washington IN: Elementary School malaise; Sports->Anderson again: High School; Real love spark; Science concentration; '48 Ford Club Coupe; Stamp collecting; Spiritual inklings->Miami: Growing up; Tropical Fish->Anderson College; Ping Pong; Biology; Beginning love->Marriage->USAF (CA, CO, NE): Photography, Learning to live/love->Coral Gables/Kendall FL: University of Miami, Shrimp/Crabs, Marisa cornurietis; One acre of Paradise; Son and then Daughter; Bachelor's and Master's->Lake Wales Florida: Warner Southern College, Teaching Biology/Marine Sciences, Vice President, Student interaction; Spiritual exploration; University of Florida, PhD->Laguna Hills CA: Missions Computer Systems; Florida Interlude (library, chaplain's assistant); Hope International University, Muslims, Teaching, Consulting->North Port FL: Seventy-one years later, blatant eclecticism, a lifetime of longing, and hours and days of years in brooding; now retired; and the song continues.


 

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