MANGOSTEEN: IT CAN CHANGE YOUR LIFE

Clinical Examples
(Unedited text from the U.S. Patent for Xango%u2122 Dietary Supplement)
The effectiveness in improving general health and wellness of the nutraceutical
mangosteen compositions described herein is demonstrated from the following clinical
examples, which are listed for illustrative purposes only and are not meant to be limiting
instances of therapeutic use. A therapeutic composition of the mangosteen fruit pulp and
pericarp mixture was prepared according to the embodiments described herein. Each
subject ingested 3 ounces of the beverage daily for a three week period.
The following qualitative results were obtained:

EXAMPLE 1
The subject was a 62-year-old female suffering from chronic back pain, nausea and
chronic vertigo. Prior to the study, the pack pain was treated with oral doses of morphine
three times a day. After a regiment of the mangosteen nutraceutical composition, the
subject experienced improved energy, less nausea and a decrease in the vertigo
symptoms.

EXAMPLE 2
The subject was a 56-year-old male suffering from chronic obstructive pulmonary
disease, muscle aches, fatigue and dysthemia. After a regiment of the mangosteen
nutraceutical composition, the subject experienced improvement in mood, energy and
muscle aches in the shoulders and back.

EXAMPLE 3
The subject was a 55-year-old male suffering from irritable bowel syndrome. After a
regiment of the mangosteen nutraceutical composition, the subject experienced
regularization of bowel movements.

EXAMPLE 4
The subject was a 30-year-old male suffering from chronic neck pain, familial
hyperlipidemia, fatigue and insomnia. After a regiment of the mangosteen nutraceutical
composition, the subject experienced improved energy and a decrease in low-density
lipoproteins.

EXAMPLE 5
The subject was a 52-year-old male suffering from hypokelemia, fatigue and weight gain.
After a regiment of the mangosteen nutraceutical composition, the subject experienced
improved energy and a normalization of potassium levels.

EXAMPLE 6
The subject was a 63-year-old female suffering from degenerative arthritis, C-difficile
colitis, fatigue, decreased appetite hypokelemia, and numbness of the fingers and toes.
After a regiment of the mangosteen nutraceutical composition, the subject experienced
improvement in colitis, reduction of pain in wrists and hands and a normalization of
potassium levels.
Clinical Examples (continued)

EXAMPLE 7
The subject was a 66-year-old male suffering from a severe allergy reaction causing
desquamation of palms, fingers, soles of feet and the inside of the mouth and esophagus.
After a regiment of the mangosteen nutraceutical composition, the subject was
completely cured.

EXAMPLE 8
The subject was a 57-year-old male suffering from malaise, muscle aches, hepatitis,
glomerionephritis, diabetes and hyperlipidemia. After a regiment of the mangosteen
nutraceutical composition, the subject experienced a 30 point decrease in low-density
lipoproteins, a 10 point increase in high-density lipoproteins, improved energy, a 14-
pound weight loss and the malaise was eliminated.

EXAMPLE 9
The subject was a 30-year-old male suffering from a chronic dermal rash. After a
regiment of the mangosteen nutraceutical composition, the rash was completely
eliminated.

EXAMPLE 10
The subject was a 25-year-old female suffering from low energy levels. After a regiment
of the mangosteen nutraceutical composition, the subject experienced increased energy.

EXAMPLE 11
The subject was a 28-year-old female suffering from extreme fatigue and depression.
After a regiment of the mangosteen nutraceutical composition, the subject experienced a
significant increase in energy.

EXAMPLE 12
The subject was a 26-year-old female suffering from irritable bowel syndrome. After a
regiment of the mangosteen nutraceutical composition, the subject experienced a
decrease in cramping and stool frequency and increased energy.

EXAMPLE 13
The subject was a 32-year-old male marathon runner and iron man competitor. After a
regiment of the mangosteen nutraceutical composition, the subject experienced increased
energy levels.

EXAMPLE 14
The subject was a 70-year-old female suffering from severe arthritis. After a regiment of
the mangosteen nutraceutical composition, the subject experienced complete elimination
of arthritic symptoms and increased energy.

SUMMARY OF MEDICAL RESEARCH ABSTRACTS
FOR MANGOSTEEN
The conclusions of following research abstracts on Mangosteen and the Mangosteen's xanthones
have been summarized below in non-technical terms for ease of reading. The complete abstracts
and additional research studies can be found on www.pubmed.gov All information provided is
for informational purposes only and is not intended as, nor should it be used as, medical advice
nor intended to diagnose, treat, cure or prevent any disease or condition. All serious health
conditions should be treated by a competent health practitioner.

LDL CHOLESTOROL
Free Radic Res. 1995 Aug; 23(2):175-84.
Mangostin inhibits the oxidative modification of human low density lipoprotein
Williams P, Ongsakul M, Proudfoot J, Croft K, Beilin L.
University of Western Australia, Department of Medicine, Royal Perth Hospital, Australia
The researchers investigated the possible antioxidant effects of the xanthone, mangostin, isolated
from the mangosteen fruit, on the oxidation of human LDL (bad cholesterol). From these results,
they concluded that mangostin is acting as a free radical scavenger ("mop up" sponge) to protect
the LDL from oxidative damage in this in vitro system. (In other words, it a potent antioxdiant).

ANTI-INFLAMMATORY
Mol Pharmacol. 2004 Sep;66(3):667-74.
gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases
lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells.
Nakatani K, Yamakuni T, Kondo N, Arakawa T, Oosawa K, Shimura S, Inoue H, Ohizumi Y.
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku
University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
The researchers investigated the effect of the xanthone, gamma-mangostin purified from the fruit
hull of the medicinal plant Garcinia mangostana (mangosteen) on the enzyeme that causes
inflammation and swelling (COX-2). They showed that gamma-mangostin selectively inhibited
the COX-2 enzyme, but not those of the COX-1 enzyme. This means that gamma-mangostin acts
as an anti-inflammatory but does not cause stomach ulcers and bleeding or kidney problems
which can be serious side effects of anti-inflammatory drugs. The researchers said that this
mangosteen xanthone is a useful lead compound for future anti-inflammatory research.

ANTI-INFLAMMATORY and ANTIHISTAMINE
Biol Pharm Bull. 2002 Sep;25(9):1137-41.
Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen,
a Thai medicinal plant
Nakatani K, Atsumi M, Arakawa T, Oosawa K, Shimura S, Nakahata N, Ohizumi Y.Department of Pharmaceutical
Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
The fruit hull of mangosteen, Garcinia mangostana L., has been used as a Thai indigenous
medicine for many years. The investigators in this study found a mangosteen fruit extract
strongly inhibited the both the release of histamines and the production of agents that cause
inflammation.

SUMMARY OF MEDICAL RESEARCH ABSTRACTS FOR MANGOSTEEN (continued)
CANCER
J Ethnopharmacol. 2004Jan;90(1):161-6.
Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana
(mangosteen) on SKBR3 human breast cancer cell line
Moongkarndi P, Kosem N, Kaslungka S, Luanratana O, Pongpan N, Neungton N.
Department of Microbiology, Faculty of Pharmacy, Mahidol University, Sri
Ayudthaya Road, Rajdhevee, Bangkok 10400, Thailand pypmk@mahidol.ac.th
These investigators found that an extract from the rind of the mangosteen fruit inhibited the
growth of breast cancer cells. They also showed that the extract had potent antioxidant and
cancer cell death properties. They concluded that the extract from the rind of the mangosteen
fruit has potential for cancer chemoprevention.
Fitoterapia. 2004 Jun;75(3-4):375-7.
Antiproliferative activity of Thai medicinal plant extracts on human breast
adenocarcinoma cell line.
Moongkarndi P, Kosem N, Luanratana O, Jongsomboonkusol S, Pongpan N.
Department of Microbiology, Faculty of Pharmacy, Mahidol University, Rajdhevee, Sri Ayudthaya Rd, Bangkok
10400, Thailand. pypmk@mahidol.ac.th
Extracts of selected nine Thai medicinal plants were tested for the ability to inhibit the growth
(antiproliferative activity) of SKBR3 human breast adenocarcinoma cell line. Garcinia
mangostana (mangosteen) showed the most potent activity and in potential range for further
investigation on cancer cells.
Planta Med. 2002 Nov; 68(11):975-9.
Garcinone E, a xanthone derivative, has potent cytotoxic effect against the
hepatocellular carcinoma cell lines
Ho CK, Huang YL, Chen CC.
Department of Medical Research & Education, Veterans General Hospital, Taipei, ROC
Treatment of liver cancer with chemotherapy has generally been disappointing. The investigators
extracted and purified 6 xanthone compounds from the rinds of the Garcinia mangostana,
mangosteen fruit. The extracts were tested on 14 different human liver cancer cell lines. Several
chemotherapy drugs were included in the study for comparison. The results showed that one of
the xanthones, garcinone E, has potent killing effects on all liver cancer cell lines as well as on
the other stomach and lung cancer cell lines included in the screen. The mangosteen xanthone
was more efficient than five chemotherapy drugs that are in use. Garcinone E may be potentially
useful for the treatment of certain types of cancer.
J Pharm Pharmacol. 1996 May; 48(5):539-44
Xanthone derivatives as potential anti-cancer drugs
Lin CN, Liou SJ, Lee TH, Chuang YC, Won SJ.
School of Pharmacy, Kaohsiung Medical College, Taiwan, ROC
Res

Former surgeon Armando de Guzman is one of the true superstars of Xango network marketing with an organization nearly 500,000 strong which is presently generating $15 million a month in Xango volume and is likely to just keep on growing. Yikes!
Armando's story, though, is incredible. As an avid amateur cyclist, he suffered a horrendous accident, and found himself with terrible post-trauma pain, mounting bills and unable to work...that's where Xango came in.

Dr. Armando de Guzman

BAYAREAJUICE.com can show the reasons.

The top 7 nutritional supplement company's in the country are network marketing companies. That's right, GNC is number 8!!! What would you do if you were XanGo and coming out with a new supplemental health beverage? The top 2 cosmetic companies in the country are network marketing companies. Revlon is # 3!!

TIME, MONEY AND FREEDOM IS EVERYONE'S DESIRE
This could be the opportunity you've been waiting for.

Now is the time to capitalize on the massive growth that XanGo Juice is experiencing in many countries.

Ordinary people are achieving extraordinary incomes in record time with the resources of a record breaking company. Now it's your turn!

* Low Startup Cost
* Proven Company and Product
* Low Over Head - Work From Home
* A Product That Works
* Unlimited Income Potential
* A Team of Leaders to Support You
* No Contracts
* No Commitments

TO ORDER YOUR XANGO TODAY: myxango.com/johnhennigan