Feelings of helplessness and hopelessness

A bleak outlook-nothing will ever get better and there's nothing you can do to improve your situation.

Loss of interest in dailly activities

No interest in or ability to enjoy former hobbies, pastimes, social activities, or sex.

Appetite or weight changes

Significant weight loss or weight gain-a change of more than 5% of body weight in a month.

Sleep changes

Either insomnia or oversleeping (also known as hypersomnia).

Either feeling "keyed up" and restless or sluggish and physically slowed down.

Loss of energy

Feeling fatigued and physically drained. Even small tasks are exhausting or take longer.

Self-loathing

Strong feelings of worthlessness or guilt. Harsh criticism of perceived faults and mistakes.

Concentration problems

Trouble focusing, making decisions, or remembering things.

Irritability

Easily annoyed or frustrated. Lashing out in anger or snapping at others.

Aches and pains

New or worse physical symptoms, including headaches, backaches, diarrhea or constipation, abdominal pain, and aching joints.