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General Hospital (commonly abbreviated GH) is an American soap opera which premiered on the ABC television network on April 1, 1963. Broadcast weekdays and currently repeated nightly on SOAPnet, it is the longest-running serial produced in Hollywood, and the longest-running entertainment program in ABC television history. General Hospital rose to the top of the ratings in the early 1980s in part thanks to the monumentally popular "supercouple" Luke and Laura, whose 1981 wedding brought in 30 million viewers and remains the highest-rated hour in American soap opera history.Wolf, Buck. "Luke and Laura: Still the Ultimate TV Wedding." ABC.com November 16, 2006.

General Hospital was created by husband-and-wife soap writers Frank and Doris Hursley, and is set in the fictional city of Port Charles, New York. Currently taped at The Prospect Studios, General Hospital originally aired for a half-hour. The series was expanded to 45 minutes in 1976, and then to a full hour in 1978. It holds the record for most Daytime Emmy Awards for Outstanding Drama Series, with 10 wins. General Hospital spawned a prime time spin-off with the same name in the United Kingdom from 1972 to 1979, as well as the daytime series Port Charles (1997-2003) and the prime time spin-off Category: General Hospital: Night Shift - (2007-2008) in the United States.

With the September 18, 2009, cancellation of CBS's Guiding Light, General Hospital will become the second longest-running soap opera in the United States, after As the World Turns, which premiered on April 2, 1956.