In 1994, Fox was cast in a co-starring role as the eldest of five siblings who lose both parents in a car accident on the 1990s teen drama, Party of Five, as Charlie Salinger. In 1996, People Magazine named Fox as one of the 50 Most Beautiful People in the World. After Party of Five was canceled after its sixth season, Fox starred in another TV series Haunted, in 2002.

Since September 2004, Fox has played the role of the troubled and dedicated surgeon, Dr. Jack Shephard, on Lost. He initially auditioned for the role of James "Sawyer" Ford. However, co-creator J.J. Abrams was so pleased with his reading of the Shephard character that Fox was cast in the lead role. As the star of the series, he is also the highest-paid actor on the show. (read more)