Use "MIGRELIEF" for Migraine Prevention

Multiple, double-blind clinical studies published in top medical journals have shown that MigreLief can have a degrading affect on migraine frequency and intensity.

MigreLief contains high doses of:

Magnesium citrate and oxide

Riboflavin (Vitamin B2)

Puracol Feverfew (proprietary extract + whole leaf)

MigreLief combines all 3 of these ingredients into one formula -- at the dosages the clinical studies show are beneficial. So you take 1 product not 3 products. And you take 2 tablets/day -- versus 4 - 10 tablets/day if taken separately. Plus, MigreLief's Puracol Feverfew contains high levels of parthenolides and other active components - which other feverfew products cannot guarantee.

Research studies show that almost half of all migraine sufferers have low blood levels of Magnesium-which is critical in controlling vasospasms (the contraction and dilation of blood vessels in the brain which occurs during migraines). Migraine sufferers also suffer mitochondrial energy deficiencies, which Riboflavin (Vitamin B2) can improve when given in high dosages. And the plant material Feverfew has been shown to reduce platelet aggregation, which can lead to vasoconstriction. So all 3 ingredients have been recommended for years by many doctors and top headache specialists based on the clinical studies behind them.

Magnesium
Magnesium is a nutritional supplement with numerous effects that support cerebrovascular tone. These include: 1) inhibition of platelet aggregation;2) interference with synthesis, release, and action of inflammatory mediators;3) direct alterations of cerebrovascular tone; 4) inhibition of vasospasm; and 5) stabilization of cell membranes. Some migraine sufferers with poor cerebrovascular tone have been found to have low brain levels of magnesium. Recommended daily dosages of magnesium typically range from 200 to 600 mg to compensate for this deficiency -- far above what's found in most multi-vitamins.

Riboflavin
Riboflavin (vitamin B-2) is a precursor of flavin adenine dinucleotide(FAD). This coenzyme is an important component of the electron-transport chain. A deficiency of mitrochondrial energy reserves has been observed in some persons exhibiting poor cerebrovascular tone. This defect may theoretically be corrected by a compound such as riboflavin that improves the activity of the electron-transport chain. MigreLief provides 400mg of Riboflavin -- significantly higher than most multi-vitamins or B-complex products.

Feverfew
Commonly recommended for its ability to support cerebrovascular tone, feverfew (Tanacetum parthenium) is rich in compounds known as sesquiterpene lactones. One of the more important of these compounds may be parthenolide, which represents 85% of the sesquiterpene lactone content in feverfew. Some scientific studies indicate that while parthenolide may be important there may very well be other phytochemicals in feverfew that are as of yet unidentified and play a role in its effectiveness. Some studies of extracts of feverfew containing parthenolide yielded no significant benefits. This led researchers to believe that certain of the unidentified phytochemicals may have been left behind during the extraction process. The ideal solution would be a non extracted feverfew product that naturally contained high levels of parthenolide and kept all of the other naturally occurring phytochemicals as well. Thus Puracol Feverfew, AKESO HEALTH SCIENCE'S proprietary non extracted plant source for feverfew with high levels of naturally occurring parthenolide was developed. Puracol Feverfew, is just one of the reasons for the superior efficacy of MigreLief which delivers optimal dosages of parthenolide. Scientific studies have found parthenolide inhibits platelet aggregation and the release of serotonin from platelets and polymorphonuclear leukocyte granules.* It has also been shown to inhibit pro-inflammatory prostaglandin synthesis and the release of arachadonic acid. Each of these phenomena are associated with migraines.* European studies have shown the benefits of feverfew on long-term cerebrovasular tone.