The Rabies Vaccine for Dogs and Cats: What You Need to Know Now

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The Rabies Vaccine Can Be Hazardous to Your Pet's Health

Most people think of vaccines as safe and protective, but vaccination is a serious medical procedure with significant risks. The rabies vaccine, in particular, is notorious when it comes to adverse reactions. Here are some potentially life-saving tips to help your dog or cat. My conclusions are the result of extensive research and interviews with countless experts. I have no ties to the pharmaceutical industry. I profit in NO way from your vaccination decisions.

Emergency: What to Do If Your Dog is Having a Reaction to the Rabies Vaccine

If your dog is breathing heavy, his face is swelling and eyes watering, and/or he's throwing up, your dog is having a potentially life-threatening allergic reaction. CALL YOUR VET IMMEDIATELY! If possible, start for your vet's office, or an emergency facility, and call on the way while some else does the driving.

If your dog develops any health problem after the shot, read the list of common reactions below. It may be an adverse reaction to the rabies shot. Your vet may not recognize it as a reaction and may not want to believe he/she brought on this problem. It's up to you to bring up the subject and investigate.

Note that your vet will likely treat the symptoms without addressing the underlying cause. Homeopathy is your best bet. Call an expert.

Important: Make sure your vet records the reaction in detail in your dog's file and get a copy of the file. Put it in a safe place. When the rabies shot is due again, ask your vet to apply for an exemption. Read our page on vaccinating before you give another shot of any kind.

Watch Our Informative (and Entertaining) Video

WATCH IT FULL-SIZE by clicking the "Comments" link below the player.

Dog Rabid About Rabies Vaccine Dangers
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Does Your Dog or Cat Really Need a Rabies Shot?

  • The rabies vaccine is the ONLY shot required by law for dogs and cats in the United States. This is primarily to protect humans from getting rabies from their pets.

  • The Center for Disease Control declared in 2007 that canine rabies no longer exists in the United States. Your dog will not contract rabies from another dog, but only from wild animals such as bats, coyotes, skunks, raccoons and foxes. Click here to read the CDC press release.

  • In most areas, only young puppies, and dogs with written exemptions from their local Animal Control, are exempt from getting this shot. (More on this later.)

  • Consequences for not vaccinating against rabies depend on the Animal Control laws in your area. At the very least, you won't be able to board your pet, participate in training classes or shows, or use a professional groomer. Many vets will insist on vaccination before boarding or treating your pet. And if your dog or cat bites or scratches anyone, or is picked up by Animal Control, there will surely be a stiff fine and your pet will be impounded and vaccinated (or worse).

Sign this Petition to Eliminate Unnecessary Vaccination

Please read and sign the Safer Vaccines for Companion Animals petition to the U.S. Government, US Governmental Agencies and American Veterinary Medical Association. Help dogs and cats get only the vaccines they absolutely need.

When Do You Have to Vaccinate?

  • Most localities require vaccination every three years even though studies in France and blood antibody tests in this country show that the rabies vaccine's immunity lasts for seven years. Worse yet, whether because of habit, ignorance or greed, some localities require annual vaccination--although the "three year" shot is guaranteed by manufacturers to give immunity for three years.

  • The one-year shot is NOT safer than the three-year shot, and has to be given more often, making it potentially more dangerous.

  • Puppies are generally required to get their first shot around four months, then again one year later and thereafter as required by local law. Check with your vet or Animal Control for details.


Read my new blog post on ELIMINATING UNNECESSARY SHOTS.

When Should You NOT Vaccinate?

Informed veterinarians generally recommend that you should NOT vaccinate:

  • Puppies younger than 4 months

  • A pet that has reacted adversely to vaccination in the past

  • A sick pet, especially a dog with cancer or an autoimmune disease (read this important article on the dangers of vaccinating unhealthy pets)

  • Before, during or after surgery, chemotherapy or other major medical procedure

  • Within 3-4 weeks of other shots

Important: When getting a new dog or cat, get shot records, too. Pets from shelters, pet stores and most rescue groups will have been recently vaccinated, as may have animals from individuals. Don't vaccinate unnecessarily. Find out exactly which shots your pet got, and when. Get documentation from the vet in question if your pet had a rabies shot.

You have options to vaccinating (discussed below) which you should discuss with your veterinarian.

Disclaimer: Jan Rasmusen is not a veterinarian. The information above is provided for information purposes only, and is not intended as a substitute for advice from a qualified health practitioner.

What Adverse Reactions are Commonly Reported?

Peaches, a top Agility star (shown here), developed Ischemic Dermatopathy -- a painful skin disease -- after a rabies shot.



After rabies vaccination, your dog may experience fever, malaise or even life-threatening anaphylactic shot. Non-immediate reactions days or even months after vaccination (called "vaccinosis") include, but aren't limited to:

  • Aggression or destructive behavior

  • Separation anxiety

  • Obsessive compulsive behaviors (like chasing tails or licking paws)

  • Seizures and epilepsy

  • Autoimmune diseases

  • Allergies

  • Skin problems

  • Digestive disorders

  • Muscle weakness

  • Pica (eating inappropriate materials)

  • Fibrocarcinomas at the injection site (particularly in cats-see below--but also in dogs)

Inexplicably, few vets warn about these possible adverse effects -- or even admit to the possibility even after they occur. If your pet experiences any of these reactions, REPORT THEM TO YOUR VET. Also know that there are things you can do. (Read on.)

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What Can You Do to Protect Your Pet?

If your dog is at high risk for contracting rabies, know that the only way to guarantee immunity to the rabies virus is with a simple blood test called an antibody titer (pronounced Tight er). Ask your vet about it.

Never give the rabies vaccine with other shots -- especially not with a combination shot (one that vaccinates against several diseases at once.) In fact, don't give combos at all. They are linked to serious adverse reactions. This is even more important for small dogs whose bodies can't withstand multiple shots at once.

***If your pet has documented health problems and a low likelihood of contracting rabies, ask your vet to apply for a rabies vaccination extension or exemption. A rabies titer test showing immunity may help your cause. Expect to pay license fees, and to reapply in the next licensing period. If your vet won't do it, consult another vet.

If you have to vaccinate, consult a vet trained in homeopathy. There's a homeopathic "remedy" that can be given with the shot to lessen the chance of ill effects. Find a vet at Holistic Vet List. Or try Homeopathy Trained Vets.

***Report ALL reactions to vaccines to your vet; make sure the reactions are recorded in your pet's file. Have the vet sign the page showing reactions. Get a copy! Documentation will be necessary if you ever need to apply for an exemption. Also, years from now, you may forget the details.

If your dog has any adverse reaction to a shot, but your vet dismisses your concerns, take matters into your own hands. Contact a holistic vet. There are things that can be done to alleviate even long-standing problems. At least, check out the links on this page (below) and do a web search. Surely, others have experienced the same problem and may have solutions.

Kennels, groomers, trainers and doggy day care facilities may require proof of rabies, but more and more establishments accept titer testing. If they require vaccination more frequently than legally required, educate them or find another establishment. Their lack of knowledge is potentially hazardous to your pet's health.

Tell them that only a titer test guarantees immunity and, because canine rabies has been declared non-existent in the US, requiring rabies shots to protect dogs from each another is illogical!

Are There Special Considerations When Traveling?

Check with your airline when flying within the Continental U.S. to see if your pet needs proof of rabies vaccination and/or a health certificate. When flying internationally, plan well ahead and check with your airline and visit Pet Travel for more information. If you're even thinking of shipping your pet in the belly of an aircraft, please read this article first.

NEVER vaccinate within a week of travel. Your animal may experience a life-threatening shot reaction and may die without immediate medical assistance.

Keep copies of your vaccination records and titer tests in your cars. Keep license tags on your dog's collar or harness. You don't want to have to revaccinate should you need to board your pet unexpectedly or should she bite someone.

Print a list of emergency vet clinics along your route at Pets911.

If you suspect your dog is suffering adverse reactions from a rabies shot, I suggest you consult a holistic (not a traditional) vet. If you treat symptoms without addressing the cause, your dog's health will surely decline. Holistic Vets, particularly those trained in homeopathy, should be able to treat the cause of the vaccinosis.

My Favorite Dog Care Book

Scared Poopless: The Straight Scoop on Dog Care

Amazon Price: $19.95 (as of 02/12/2012)Buy Now

I wrote this book! It won two national awards: the Ben Franklin Award for the Best Health Book of any kind and the USABookNews Award for the Best Pet Health Book.

The Journal of the American Holistic Veterinary Medical Association wrote: This is a wonderful book! It's also endorsed by Animal Wellness Magazine, The Animal Protection Institute and countless veterinarians. All author royalties benefit animal causes.

The title alone should tell you it's not your average dog care book. Scared Poopless is heavily researched and packed with information from my two years of research and interviews --but it's also really fun to read and contains 89 wild full-color photos. It makes a beautiful, and thoughtful, gift for dog-loving friends.

In addition to an in-depth, but easy to read, chapter on vaccination, it covers food, pet meds, anesthesia and surgery and dozens of other subjects on holistic dog health and safety. Please read the reviews, and see the Table of Contents, at Amazon or my website (link below) to learn more about it.

Do Cats Have Special Needs?

Dr. Jean Hofve, DVM and former Editor-in-Chief of The American Holistic Veterinary Medical Association Journal, writes: Ideally, for cats the Merial Purevax recombinant vaccine can be used in place of the older killed vaccines that can cause injection-site tumors. She adds: When vaccines were given between the shoulder blades, these cancers were inoperable because they would grow into the spine, ribcage, and chest. This became such a serious problem that now it is recommended to give the rabies vaccine in the right hind leg so that when a tumor does develop, the whole leg can be amputated and thus the cat's life can be saved.

For more information on cat shots, go to Dr. Jean's terrific CAT website Little Big Cat. Also check out Cat Shots.

Important Links

There are countless websites with out-of-date and misleading information about vaccination for dogs and cats. Many are sponsored by people or companies benefiting from the sale or administering of vaccines. Although I can't guarantee all information on other people's sites, the following are links I personally like.
My Website and E-newsletter
Learn more about my research, holistic dog care, buying a healthy puppy, anesthesia-free dental care, vaccine damage, Maltese dogs, and much more.

Get alerted when I publish another Squidoo page. My free e-newsletter comes out 6 times a year and contains lots of information on dog care and safety plus important health alerts. You can learn more about it, and sign up, at my website.
AAHA 2006 Canine Vaccine Task Force Report
The American Animal Hospital Association Taskforce examined the safety and efficacy of canine vaccines in 2003 and 2006, changing vaccination recommendations for vet schools and organizations throughout the US. Follow this link, then click on the small red link: 2006 AAHA Canine Vaccine Guidelines-Revised.
Truth4Dogs.org
This is another website of mine with even more information about rabies vaccination.
Dogs Adverse Reactions
This link will take you directly to this site's vaccine problems page. It has other great pages on drugs that can harm your pets.
Rabies Threat to Humans
Click the Health Care Practitioners or Adult signpost for information about the rabies threat to humans.
Animal Talk Naturally Podcast
Host Kim Bloomer hosts an info-packed 60 minute interview with rabies vaccine experts Dr. Jean Dodds and Kris L. Christine, founders of the Rabies Challenge Fund. Recorded 7/31/08.
Vaccine Side Effects Anecdotes
On-line anecdotes about vaccination side effects.
General Vaccination Information
Find my video Vaccinating Dogs and links to important articles on Vaccine Damage, breeds predisposed to vaccine damage, and more.
AVMA on Vaccination Site Tumors
This discusses treatment options for tumors in cats caused by vaccines, but much of it also applies to dogs.
Which Cat Shots to Give
Poke around this website to find important information.
Follow me (K9Author) on Twitter
Get health alerts and my new articles by following me on Twitter. I only post when I have something important for your dog.
Vaccinating Unhealthy Pets: Expect Reactions and Failures
Pets that may experience reactions or immunity failures include, but aren't limited to, pets with autoimmune disease %u2026 pets undergoing chemo, radiation or surgery (even dental cleaning or neutering) %u2026 pets with autoimmune disease, cancer, severe allergies and skin diseases %u2026 pets fighting an illness or parasites %u2026 pets stressed from shipment or a move to a new home %u2026 malnourished pets %u2026 and dying housebound pets. Learn more by reading this article.
Vaccinating Dogs: 10 Steps to Eliminating Unnecessary Shots
Actually IMPROVE your dog's health by eliminating these shots.
Aimee's Medical Exemption Blog
Pamela Picard's blog arguing for rabies medical exemption in Texas and nationwide for sick and senior pets.

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Truth4Dogs Blog is all about holistic dog care, exposing the myths, misunderstanding and advertising propaganda damaging our dogs' health. Subscribe via e-mail or your favorite RSS feeder.
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Other Books and DVDs I like on Vaccinating

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Help Change Dangerous and Antiquated Rabies Vaccination Laws

World famous pet vaccination experts Drs. Jean Dodds and Ronald Schultz (Chair of the Department of Pathobiology at the University of Wisconsin, Madison) are volunteering their efforts (and the University has waived its usual overhead fee). They're doing five- and seven-year studies to test duration of vaccine protection so that we can vaccinate our animals less frequently. They will also test the safety of the shot's ingredients and establish a much-needed reporting system for adverse shot reactions.

The Challenge Fund has raised money for the first year, but needs to fund future years. Learn more about the vaccine and their work, or donate to this wonderful cause, at Rabies Challenge Fund Note: the term challenge refers to the type of testing. They are NOT challenging the need for the vaccine.

As of the Spring of 2008, Kansas and Wyoming are rethinking their laws. Arkansas is next. If you want to get e-mail alerts about how you can help, click Rabies Alert and ask to be added to the e-mail list.

Disclaimer: Jan Rasmusen is a researcher and author, not a veterinarian. Please consult a knowledgeable health care practitioner for more information or if your dog shows signs of illness.

Tell Me About Your Experiences with the Rabies Vaccine -- And Read Others' Stories

Please post your question or comment also at Truth4Dogs.com blog so others can read it.

IF YOU WANT A RESPONSE, YOU MUST COPY YOUR RESPONSE AT MY BLOG: Truth4Dogs Rabies Vaccine Info. I'll try to help. Find information on other shots at Vaccinating Dogs: What Your Vet Won't Tell You.

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    Ralph Dec 10, 2011 @ 11:01 am | delete
    CLINICAL APPROACHES TO MANAGING AND TREATING ADVERSE VACCINE REACTIONS
    W. Jean Dodds, DVM
    HEMOPET
    938 Stanford Street
    Santa Monica, CA 90403
    (310) 828-4804;FAX (310)-453-5240
    www.hemopet.org; hemopet@hotmail.com

    Background
    There is no doubt that application of modern vaccine technology has permitted us to protect companion animals effectively against serious infectious diseases.

    Viral disease and recent vaccination with single or combination modified live-virus (MLV) vaccines, especially those containing distemper virus, adenovirus 1 or 2, and parvovirus are increasingly recognized contributors, albeit relatively rare, to immune-mediated blood disease, bone marrow failure, and organ dysfunction. Potent adjuvanted killed vaccines like those for rabies virus also can trigger immediate and delayed (vaccinosis) adverse vaccine reactions. Genetic predisposition to these disorders in humans has been linked to the leucocyte antigen D-related gene locus of the major histocompatibility complex, and is likely to have parallel associations in domestic animals.

    It must be recognized, however, that we have the luxury of asking such questions today only because the risk of disease has been effectively reduced by the widespread use of vaccination programs.

    Adverse Events Associated with Vaccination
    The clinical signs associated with vaccine reactions typically include fever, stiffness, sore joints and abdominal tenderness, susceptibility to infections, neurological disorders and encephalitis, collapse with autoagglutinated red blood cells and icterus (autoimmune hemolytic anemia, AIHA, also called immune-mediated hemolytic anemia, IMHA), or generalized petechiae and ecchymotic hemorrhages (immune-mediated thrombocytopenia , ITP). Hepatic enzymes may be markedly elevated, and liver or kidney failure may occur by itself or accompany bone marrow suppression.

    Furthermore, MLV vaccination has been associated with the development of transient seizures in puppies and adult dogs of breeds or cross-breeds susceptible to immune-mediated diseases especially those involving hematologic or endocrine tissues (e.g. AIHA, ITP, autoimmune thyroiditis). Post-vaccinal polyneuropathy is a recognized entity associated occasionally with the use of distemper, parvovirus, rabies and presumably other vaccines. This can result in various clinical signs including muscular atrophy, inhibition or interruption of neuronal control of tissue and organ function, muscular excitation, incoordination and weakness, as well as seizures.

    Certain breeds or families of dogs appear to be more susceptible to adverse vaccine reactions, particularly post-vaccinal seizures, high fevers, and painful episodes of hypertrophic osteodystrophy (HOD). Therefore, we have the responsibility to advise companion animal breeders and caregivers of the potential for genetically susceptible littermates and relatives to be at increased risk for similar adverse vaccine reactions. In popular (or rare) inbred and linebred animals, the breed in general can be at increased risk as illustrated in the examples below.

    Polyvalent MLV vaccines which multiply in the host elicit a stronger antigenic challenge to the animal and should mount a more effective and sustained immune response. However, this can overwhelm the immunocompromised or even a healthy host that has ongoing exposure to other environmental stimuli as well as a genetic predisposition that promotes adverse response to viral challenge. The recently weaned young puppy or kitten being placed in a new environment may be at particular risk. Furthermore, while the frequency of vaccinations is usually spaced 2-3 weeks apart, some veterinarians have advocated vaccination once a week in stressful situations; a practice makes little sense scientifically or medically.

    An augmented immune response to vaccination is seen in dogs with pre-existing inhalant allergies (atopy) to pollens. Furthermore, the increasing current problems with allergic and immunological diseases have been linked to the introduction of MLV vaccines more than 20 years ago. While other environmental factors no doubt have a contributing role, the introduction of these vaccine antigens and their environmental shedding may provide the final insult that exceeds the immunological tolerance threshold of some individuals in the pet population. The accumulated evidence indicates that vaccination protocols should no longer be considered as a ?one size fits all? program.

    In cats, while adverse vaccine reactions may be less common, aggressive tumors (fibrosarcomas) can occasionally arise at the site of vaccination. A recent study from Italy reported finding similar tumors in dogs at the injection sites of vaccinations (Vascellari et al, 2003). These investigators stated that their ?study identified distinct similarities between canine fibrosarcomas from presumed injection sites and feline post-vaccinal fibrosarcomas, suggesting the possibility of the development of post-injection
    sarcomas not only in cats, but also in dogs?.

    Additionally, vaccination of pet and research dogs with polyvalent vaccines containing rabies virus or rabies vaccine alone was shown to induce production of antithyroglobulin autoantibodies, a provocative and important finding with implications for the subsequent development of hypothyroidism (Scott-Moncrieff et al, 2002).

    For these special cases, appropriate alternatives to current vaccine practices include:
    1) measuring serum antibody titers;
    2) avoidance of unnecessary vaccines or over vaccinating;
    3) caution in vaccinating sick or febrile individuals; and
    4) tailoring a specific minimal vaccination protocol for dogs of breeds or families known to be at increased risk for adverse reactions.
    5) considerations include starting the vaccination series later, such as at nine or ten weeks of age when the immune system is more able to handle antigenic challenge;
    6) alerting the caregiver to pay particular attention to the puppy's behavior and overall health after the second or subsequent boosters; and
    7) avoiding revaccination of individuals already experiencing a significant adverse event. Littermates of affected puppies should be closely monitored after receiving additional vaccines in a puppy series, as they too are at higher risk.

    Serologic Vaccine Titer Testing
    Some veterinarians have challenged the validity of using vaccine titer testing to assess the immunologic status of animals against the common, clinically important infectious diseases.

    With all due respect, this represents a misunderstanding of what has been called the ?fallacy of titer testing?, because research has shown that once an animal's titer stabilizes it is likely to remain constant for many years. Properly immunized animals have sterilizing immunity that not only prevents clinical disease but also prevents infection, and only the presence of antibody can prevent infection. As stated by eminent expert Dr. Ronald Schultz in discussing the value of vaccine titer testing, these tests ?show that an animal with a positive test has sterilizing immunity and should be protected from infection. If that animal were vaccinated it would not respond with a significant increase in antibody titer, but may develop a hypersensitivity to vaccine components (e.g. fetal bovine serum). Furthermore, the animal doesn't need to be revaccinated and should not be revaccinated since the vaccine could cause an adverse reaction (hypersensitivity disorder). You should avoid vaccinating animals that are already protected. It is often said that the antibody level detected is ?only a snapshot in time". That's simply not true; it is more a ?motion picture that plays for years".

    Furthermore, protection as indicated by a positive titer result is not likely to suddenly drop-off unless an animal develops a medical problem such as cancer or receives high or prolonged doses of immunosuppressive drugs. Viral vaccines prompt an immune response that lasts much longer than that elicited by classic antigen. Lack of distinction between the two kinds of responses may be why practitioners think titers can suddenly disappear.

    But, not all vaccines produce sterilizing immunity. Those that do include: distemper virus, adenovirus, and parvovirus in the dog, and panleukopenia virus in the cat. Examples of vaccines that produced non-sterile immunity would be leptospirosis, bordetella, rabies virus, herpesvirus and calicivirus --- the latter two being upper respiratory viruses of cats. While non-sterile immunity may not protect the animal from infection, it should keep the infection from progressing to severe clinical disease.

    Therefore, interpreting titers correctly depends upon the disease in question. Some titers must reach a certain level to indicate immunity, but with other agents like those that produce sterile immunity, the presence of any measurable antibody shows protection. The positive titer test result is fairly straightforward, but a negative titer test result is more difficult to interpret, because a negative titer is not the same thing as a zero titer and it doesn't necessarily mean that animal is unprotected. A negative result usually means the titer has failed to reach the threshold of providing sterile immunity. This is an important distinction, because for the clinically important distemper and parvovirus diseases of dogs, and panleukopenia of cats, a negative or zero antibody titer indicates that the animal is not protected against canine parvovirus and may not be protected against canine distemper virus or feline panleukopenia virus.

    Finally, what does more than a decade of experience with vaccine titer testing reveal ? Published studies in refereed journals show that 90-98% of dogs and cats that have been properly vaccinated develop good measurable antibody titers to the infectious agent measured. So, in contrast to the concerns of some practitioners, using vaccine titer testing as a means to assess vaccine-induced protection will likely result in the animal avoiding needless and unwise booster vaccinations.

    Our recent study (Twark and Dodds, 2000), evaluated 1441 dogs for CPV antibody titer and 1379 dogs for CDV antibody titer. Of these, 95.1 % were judged to have adequate CPV titers, and nearly all (97.6 %) had adequate CDV titers. Vaccine histories were available for 444 dogs (CPV) and 433 dogs (CDV). Only 43 dogs had been vaccinated within the previous year, with the majority of dogs (268 or 60%) having received a booster vaccination 1-2 years beforehand. On the basis of our data, we concluded that annual revaccination is unnecessary. Similar findings and conclusions have been published recently for dogs in New Zealand (Kyle et al, 2002), and cats (Scott and Geissinger, 1999; Lappin et al, 2002). Comprehensive studies of the duration of serologic response to five viral vaccine antigens in dogs and three viral vaccine antigens in cats were recently published by researchers at Pfizer Animal Health (Mouzin et al, 2004).
    When an adequate immune memory has already been established, there is little reason to introduce unnecessary antigen, adjuvant, and preservatives by administering booster vaccines. By titering triennially or more often, if needed, one can assess whether a given animal's humoral immune response has fallen below levels of adequate immune memory. In that event, an appropriate vaccine booster can be administered.
    Other Issues with Over Vaccination
    Other issues arise from over vaccination, as the increased cost in time and dollars spent needs to be considered, despite the well-intentioned solicitation of clients to encourage annual booster vaccinations so that pets also can receive a wellness examination. Giving annual boosters when they are not necessary has the client paying for a service which is likely to be of little benefit to the pet's existing level of protection against these infectious diseases. It also increases the risk of adverse reactions from the repeated exposure to foreign substances.

    Compliance or Resistence to Current Vaccine Guidelines ?
    For more than a decade, the issues discussed above on overvaccination and vaccine safety for companion animals have been raised by vaccinologists and veterinary clinicians. But, how has this still controversial knowledge impacted the veterinary profession and pet owner today? Have veterinarians really embraced the national policies on vaccination guidelines? Does the public trust veterinarians to be up-to-date on these issues or are they unsure? Do they believe veterinarians have a conflict of interest if they seek the income from annual booster vaccinations? Given media information regarding autism and measles vaccination, the public is more aware and worried about vaccine safety.
    Some veterinarians today still tell their clients there is no scientific evidence linking vaccinations with adverse effects and serious illness. This is ignorance, and confuses an impressionable client. On the other hand, vaccine zealots abound with hysteria and misinformation. None of these polarized views is helpful.

    Veterinarians are still routinely vaccinating ill dogs and those with chronic diseases or prior adverse vaccine reactions. This is especially problematic for rabies boosters, as many colleagues believe they have no legal alternative, even though the product label states it's intended for healthy animals. See www.rabieschallengefund.org

    New Breakthroughs
    Failure to standardize the legal mandate for rabies vaccinations nationwide is medically and scientifically unwarranted. The fact that individual states, counties and cities elect to mandate annual rabies boosters despite federally licensed three-year rabies vaccines is misguided.
    Now that Arkansa passed a new rabies law authorizing the State Health Department to establish rabies vaccination schedules which adopt a 3-year rabies protocol for dogs and cats (February 2009), Alabama just changed their rabies law to 3 years on August 1, 2009. However, some individual cities and counties still require annual rabies booster vaccination. For Cheyenne, WY and Wichita, KS, pressure from the public and the local veterinary associations effected a recent change to every three years.
    Despite these recent changes, the practice of rabies booster vaccination in these states and local areas has been left as optional at the discretion of the client's veterinarian. So this is a Catch-22 situation, because if the veterinarian still believes the rabies booster should be given annually instead of as licensed, they usually can talk their client into doing so.
    Rabies Vaccines and the USDA/CVB
    Rabies vaccines are the most common group of biological products identified in adverse event reports received by the USDA's Center for Veterinary Biologics (CVB). Currently, 14 rabies vaccines are labeled for use in dogs. These vaccines must meet the standard requirements established in the Title 9 Code of Federal Regulations. This requires that the vaccine provide a protected fraction of ? 83% when comparing vaccinated animals versus control animals. Also, all rabies vaccines are evaluated for safety prior to licensure, which includes performance of a field safety trial. Additionally, each serial of rabies vaccine is tested for potency by use of the National Institutes of Health potency test or another test approved by the CVB, and is tested for safety in the host and laboratory animals.

    Safety Review
    Before licensure, a product must be shown to be safe through a combination of safety evaluations. The field safety trial is the most comprehensive evaluation and has the objective of assessing the safety of the product in its target population under the conditions of its intended use. However, safety studies before licensure may not detect all safety concerns for a number of reasons, as follows: insufficient number of animals for low frequency events, insufficient duration of observation, sensitivities of subpopulations (eg, breed, reproductive status, and unintended species), or interactions with concomitantly administered products.

    State and Local Authority for Rabies Control Programs
    Although the CVB licenses veterinary biological products for use in the prevention of rabies, it is the state and local authorities govern and administer their respective rabies animal control programs. Some of these programs allow exemptions to the vaccination requirements, if medical concerns exist related to potential adverse events, but more commonly, others do not allow exemptions, regardless of the justification.

    Reporting Adverse Vaccine Reaction to Manufacturer and the Government
    There is no mandatory reporting of adverse reactions in veterinary medicine. The 2007 World Small Animal Veterinary Association (WSAVA) Vaccine Guidelines states that there is: "gross under-reporting of vaccine-associated adverse events which impedes knowledge of the ongoing safety of these products." WSAVA 2007 Vaccine Guidelines http://www.wsava.org/SAC.htm,
    Even in humans, where mandatory reporting of adverse vaccine reactions is required, Dr. David Kessler, former head of the Food & Drug Administration, reported that "only about 1% of serious events are reported to the FDA". [JAMA .269:.2785, 1993]. This problem of under-reporting has persisted for many years.
    Despite the serious under-reporting of vaccinal adverse reactions, the 2008 Report from the USDA's CVB [JAVMA 232:1000-1002, 2008], states that between April 1, 2004 and March 31, 2007, they "requested manufacturers of rabies vaccines to provide adverse event report summaries for their products. During this period, nearly 10,000 adverse event reports (all animal species) were received by manufacturers of rabies vaccines. Approximately 65% of the manufacturer's reports involved dogs."
    The USDA/CVB 2008 Report further states that "Rabies vaccines are the most common group of biological products identified in adverse event reports received by the CVB." During the 3-year period covered in this report, the CVB received 246 adverse event reports for dogs in which a rabies vaccine was identified as one of the products administered. Reports were assessed for causality, and of these,

    217 reports were considered possibly related to ? 1 of the vaccines given, 7 were considered unlikely, and 22 were assessed as unknown. Of reports with age information (n = 206), 21.4% of the dogs were ? 6 months old, 33.5% were > 6 months old but ? 2 years old, and 45.1% were > 2 years old. Of reports with sex information (n = 209), 54.5% of the dogs were female.

    The following clinical terms were listed ?to describe possibly related adverse events in dogs vaccinated against rabies? and reported to the USDA/CVB between April 1, 2004-March 31, 2007. For 217 adverse event reports ? the clinical term is followed by the % of dogs affected:
    Vomiting-28.1%; facial swelling-26.3%; injection site swelling or lump-19.4%; lethargy-12%; urticaria-10.1%; circulatory shock-8.3%; injection site pain-7.4%; pruritus-7.4%; injection site alopecia or hair loss-6.9%; death-5.5%; lack of consciousness-5.5; diarrhea-4.6%; hypersensitivity (not specified)-4.6%; fever-4.1%;, anaphylaxis-2.8%; ataxia-2.8%; lameness-2.8%; general signs of pain-2.3%; hyperactivity-2.3%; injection site scab or crust-2.3%;, muscle tremor-2.3%; tachycardia-2.3%; and thrombocytopenia-2.3%.

    The overall adverse report rate for rabies vaccines was determined to be 8.3 reports/100,000 doses sold. Adverse events considered possibly related to vaccination included acute hypersensitivity (59%); local reactions (27%); systemic reactions, which refers to short-term lethargy, fever, general pain, anorexia, or behavioral changes, with or without gastrointestinal disturbances starting within 3 days after vaccination (9%); autoimmune disorders (3%); and other (2%). In nearly 72% of the dogs of these reports, other vaccine or medicinal products were administered in conjunction with the rabies vaccine. In those instances, it was generally not possible to determine which product or products might be most closely linked to the adverse event. Additionally, in some instances, dogs had > 1 clinical sign, resulting in the coding of several clinical signs in a single report.

    But, IF one applied the only 1% estimated reporting figure of "serious" events from the former head of the FDA to the 10,000 adverse events reported for animal rabies vaccines, 65% of which were in dogs, then the actual number of dogs that had adverse reactions to the vaccine could be as high as 650,000 in that 3 year period with 3,575 (5.5%) of the dogs dying from their adverse reaction.

    Treatment of Vaccinosis
    The diagnosis of vaccinosis is an exclusionary one -- i.e. nothing will be found upon other testing to explain the symptoms. The animal is given the oral homeopathics, Thuja (for all vaccines other than rabies), and Lyssin to detox the rabies ?miasm?. IF there are no holistic veterinarians in the area, these homeopathics can be obtained from www.naturalrearing.com.

    Our therapy typically uses steroids in tapering doses over 4-6 weeks to stop the inflammatory process and clinical symptoms. Therapy begins with an injection of dexamethasone phosphate first, and if the animal improves right away, is continued with prednisone at 0.5 mg per pound twice daily for 5-7 days, then tapered gradually over the next month to every other day. The use of steroids will cause an increase in water intake and urination, but the animal should be able to handle the drug at these tapering doses for a few weeks. IF a holistic veterinarian wants to try an alternative therapy to steroids, this approach can also work. Try it for several days to see if it will work.

    We advise that these patients receive no further vaccine boosters, except for rabies, where exemption can be sought on a case-by-case basis but may not be granted in the specific locale.
    References

    ? Dodds WJ. More bumps on the vaccine road. Adv Vet Med 41:715-732, 1999.
    ? Dodds WJ. Vaccination protocols for dogs predisposed to vaccine reactions. J Am An Hosp Assoc 38: 1-4, 2001.
    ? Hogenesch H, Azcona-Olivera J, Scott-Moncreiff C, et al. Vaccine-induced autoimmunity in the dog. Adv Vet Med 41: 733-744, 1999.
    ? Hustead DR, Carpenter T, Sawyer DC, et al. Vaccination issues of concern to practitioners. J Am Vet Med Assoc 214: 1000-1002, 1999.
    ? Kyle AHM, Squires RA, Davies PR. Serologic status and response to vaccination against canine distemper (CDV) and canine parvovirus (CPV) of dogs vaccinated at different intervals. J Sm An Pract, June 2002.
    ? Lappin MR, Andrews J, Simpson D, et al. Use of serologic tests to predict resistance to feline herpesvirus 1, feline calicivirus, and feline parvovirus infection in cats. J Am Vet Med Assoc 220: 38-42, 2002.
    ? McGaw DL, Thompson M, Tate, D, et al. Serum distemper virus and parvovirus antibody titers among dogs brought to a veterinary hospital for revaccination. J Am Vet Med Assoc 213: 72-75, 1998.
    ? Moore GE, Glickman LT. A perspective on vaccine guidelines and titer tests for dogs. J Am Vet Med Assoc 224: 200-203. 2004.

    ? Moore et al, Adverse events diagnosed within three days of vaccine administration in dogs. J Am Vet Med Assoc 227:1102?1108, 2005.

    ? Mouzin DE, Lorenzen M J, Haworth, et al. Duration of serologic response to five viral antigens in dogs. J Am Vet Med Assoc 224: 55-60, 2004.
    ? Mouzin DE, Lorenzen M J, Haworth, et al. Duration of serologic response to three viral antigens in cats. J Am Vet Med Assoc 224: 61-66, 2004.
    ? Paul MA.Credibility in the face of controversy. Am An Hosp Assoc Trends Magazine XIV(2):19-21,1998.
    ? Paul MA (chair) et al. Report of the AAHA Canine Vaccine Task Force: 2003 canine vaccine guidelines, recommendations, and supporting literature. AAHA, April 2003, 28 pp.
    ? Paul MA (chair) et al. Report of the AAHA Canine Vaccine Task Force : 2006 AAHA Canine Vaccine Guidelines. J Am An Hosp Assoc 42:80-109, Mar-April 2006, 28 pp. www.aahanet.org
    ? Richards JR (chair) et al. The 2006 American Association of Feline Practitioners Feline Vaccine Advisory Report . J Am Vet Med Assoc 229:1405-1441, 2006. www.aafponline.org

    ? Schultz RD. Current and future canine and feline vaccination programs. Vet Med 93:233-254, 1998.
    ? Schultz RD, Ford RB, Olsen J, Scott F. Titer testing and vaccination: a new look at traditional practices. Vet Med, 97: 1-13, 2002 (insert).
    ? Scott FW, Geissinger CM. Long-term immunity in cats vaccinated with an inactivated trivalent vaccine. Am J Vet Res 60: 652-658, 1999.
    ? Scott-Moncrieff JC, Azcona-Olivera J, Glickman NW, et al. Evaluation of antithyroglobulin antibodies after routine vaccination in pet and research dogs. J Am Vet Med Assoc 221: 515-521, 2002.
    ? Smith CA. Are we vaccinating too much? J Am Vet Med Assoc 207:421-425, 1995.
    ? Tizard I, Ni Y. Use of serologic testing to assess immune status of companion animals. J Am Vet Med Assoc 213: 54-60, 1998.
    ? Twark L, Dodds WJ. Clinical application of serum parvovirus and distemper virus antibody titers for determining revaccination strategies in healthy dogs. J Am Vet Med Assoc 217:1021-1024, 2000.
    ? Vascellari M, Melchiotti E, Bozza MA et al. Fibrosarcomas at presumed sites of injection in dogs: characteristics and comparison with non-vaccination site fibrosarcomas and feline post-vaccinal firosarcomas. J Vet Med 50 (6): 286-291, 2003.

    CANINE VACCINE ADVERSE EVENTS *
    ? retrospective cohort study; 1.25 million dogs vaccinated at 360 veterinary hospitals
    ? 38 adverse events per 10,000 dogs vaccinated
    ? inversely related to dog weight
    ? vaccines prescribed on a 1-dose-fits-all basis, rather than by body weight.
    ? increased for dogs up to 2 yr of age, then declined
    ? greater for neutered versus sexually intact dogs
    ? increased as number of vaccines given together increased
    ? increased after the 3 rd or 4 th vaccination
    ? genetic predisposition to adverse events documented
    _____________________________________________________________
    * from Moore et al, JAVMA 227:1102?1108, 2005

    VACCINE CONCLUSIONS FOR CANINES *
    Factors that increase risk of adverse events 3 days after vaccination:

    ? young adult age
    ? small-breed size
    ? neutering
    ? multiple vaccines given per visit
    These risks should be communicated to clients
    _______________________________________________________
    * from Moore et al, JAVMA 227:1102?1108, 2005

    FELINE VACCINE ADVERSE EVENTS *
    ? retrospective cohort study; 0.5 million cats vaccinated at 329 veterinary hospitals
    ? 51.6 adverse events per 10,000 cats vaccinated
    ? inversely related to cat weight
    ? increased for cats about 1 yr of age
    ? greater for neutered versus sexually intact cats
    ? increased as number of vaccines given together increased
    ? Lethargy with or without fever was most common sign
    _________________________________________________
    * from Moore et al, JAVMA 231:94-100, 2007

    VACCINE CONCLUSIONS FOR FELINES *
    Factors that increase risk of adverse events 30 days after vaccination:
    ? young adult age
    ? neutering
    ? multiple vaccines given per visit
    These risks should be communicated to clients, and the number
    of vaccines administered concurrently limited
    _______________________________________________________
    * from Moore et al, JAVMA 231:94-100, 2007
  • Reply
    concerned pet owner Dec 10, 2011 @ 11:00 am | delete
    CLINICAL APPROACHES TO MANAGING AND TREATING ADVERSE VACCINE REACTIONS
    W. Jean Dodds, DVM
    HEMOPET
    938 Stanford Street
    Santa Monica, CA 90403
    (310) 828-4804;FAX (310)-453-5240
    www.hemopet.org; hemopet@hotmail.com

    Background
    There is no doubt that application of modern vaccine technology has permitted us to protect companion animals effectively against serious infectious diseases.

    Viral disease and recent vaccination with single or combination modified live-virus (MLV) vaccines, especially those containing distemper virus, adenovirus 1 or 2, and parvovirus are increasingly recognized contributors, albeit relatively rare, to immune-mediated blood disease, bone marrow failure, and organ dysfunction. Potent adjuvanted killed vaccines like those for rabies virus also can trigger immediate and delayed (vaccinosis) adverse vaccine reactions. Genetic predisposition to these disorders in humans has been linked to the leucocyte antigen D-related gene locus of the major histocompatibility complex, and is likely to have parallel associations in domestic animals.

    It must be recognized, however, that we have the luxury of asking such questions today only because the risk of disease has been effectively reduced by the widespread use of vaccination programs.

    Adverse Events Associated with Vaccination
    The clinical signs associated with vaccine reactions typically include fever, stiffness, sore joints and abdominal tenderness, susceptibility to infections, neurological disorders and encephalitis, collapse with autoagglutinated red blood cells and icterus (autoimmune hemolytic anemia, AIHA, also called immune-mediated hemolytic anemia, IMHA), or generalized petechiae and ecchymotic hemorrhages (immune-mediated thrombocytopenia , ITP). Hepatic enzymes may be markedly elevated, and liver or kidney failure may occur by itself or accompany bone marrow suppression.

    Furthermore, MLV vaccination has been associated with the development of transient seizures in puppies and adult dogs of breeds or cross-breeds susceptible to immune-mediated diseases especially those involving hematologic or endocrine tissues (e.g. AIHA, ITP, autoimmune thyroiditis). Post-vaccinal polyneuropathy is a recognized entity associated occasionally with the use of distemper, parvovirus, rabies and presumably other vaccines. This can result in various clinical signs including muscular atrophy, inhibition or interruption of neuronal control of tissue and organ function, muscular excitation, incoordination and weakness, as well as seizures.

    Certain breeds or families of dogs appear to be more susceptible to adverse vaccine reactions, particularly post-vaccinal seizures, high fevers, and painful episodes of hypertrophic osteodystrophy (HOD). Therefore, we have the responsibility to advise companion animal breeders and caregivers of the potential for genetically susceptible littermates and relatives to be at increased risk for similar adverse vaccine reactions. In popular (or rare) inbred and linebred animals, the breed in general can be at increased risk as illustrated in the examples below.

    Polyvalent MLV vaccines which multiply in the host elicit a stronger antigenic challenge to the animal and should mount a more effective and sustained immune response. However, this can overwhelm the immunocompromised or even a healthy host that has ongoing exposure to other environmental stimuli as well as a genetic predisposition that promotes adverse response to viral challenge. The recently weaned young puppy or kitten being placed in a new environment may be at particular risk. Furthermore, while the frequency of vaccinations is usually spaced 2-3 weeks apart, some veterinarians have advocated vaccination once a week in stressful situations; a practice makes little sense scientifically or medically.

    An augmented immune response to vaccination is seen in dogs with pre-existing inhalant allergies (atopy) to pollens. Furthermore, the increasing current problems with allergic and immunological diseases have been linked to the introduction of MLV vaccines more than 20 years ago. While other environmental factors no doubt have a contributing role, the introduction of these vaccine antigens and their environmental shedding may provide the final insult that exceeds the immunological tolerance threshold of some individuals in the pet population. The accumulated evidence indicates that vaccination protocols should no longer be considered as a ?one size fits all? program.

    In cats, while adverse vaccine reactions may be less common, aggressive tumors (fibrosarcomas) can occasionally arise at the site of vaccination. A recent study from Italy reported finding similar tumors in dogs at the injection sites of vaccinations (Vascellari et al, 2003). These investigators stated that their ?study identified distinct similarities between canine fibrosarcomas from presumed injection sites and feline post-vaccinal fibrosarcomas, suggesting the possibility of the development of post-injection
    sarcomas not only in cats, but also in dogs?.

    Additionally, vaccination of pet and research dogs with polyvalent vaccines containing rabies virus or rabies vaccine alone was shown to induce production of antithyroglobulin autoantibodies, a provocative and important finding with implications for the subsequent development of hypothyroidism (Scott-Moncrieff et al, 2002).

    For these special cases, appropriate alternatives to current vaccine practices include:
    1) measuring serum antibody titers;
    2) avoidance of unnecessary vaccines or over vaccinating;
    3) caution in vaccinating sick or febrile individuals; and
    4) tailoring a specific minimal vaccination protocol for dogs of breeds or families known to be at increased risk for adverse reactions.
    5) considerations include starting the vaccination series later, such as at nine or ten weeks of age when the immune system is more able to handle antigenic challenge;
    6) alerting the caregiver to pay particular attention to the puppy's behavior and overall health after the second or subsequent boosters; and
    7) avoiding revaccination of individuals already experiencing a significant adverse event. Littermates of affected puppies should be closely monitored after receiving additional vaccines in a puppy series, as they too are at higher risk.

    Serologic Vaccine Titer Testing
    Some veterinarians have challenged the validity of using vaccine titer testing to assess the immunologic status of animals against the common, clinically important infectious diseases.

    With all due respect, this represents a misunderstanding of what has been called the ?fallacy of titer testing?, because research has shown that once an animal's titer stabilizes it is likely to remain constant for many years. Properly immunized animals have sterilizing immunity that not only prevents clinical disease but also prevents infection, and only the presence of antibody can prevent infection. As stated by eminent expert Dr. Ronald Schultz in discussing the value of vaccine titer testing, these tests ?show that an animal with a positive test has sterilizing immunity and should be protected from infection. If that animal were vaccinated it would not respond with a significant increase in antibody titer, but may develop a hypersensitivity to vaccine components (e.g. fetal bovine serum). Furthermore, the animal doesn't need to be revaccinated and should not be revaccinated since the vaccine could cause an adverse reaction (hypersensitivity disorder). You should avoid vaccinating animals that are already protected. It is often said that the antibody level detected is ?only a snapshot in time". That's simply not true; it is more a ?motion picture that plays for years".

    Furthermore, protection as indicated by a positive titer result is not likely to suddenly drop-off unless an animal develops a medical problem such as cancer or receives high or prolonged doses of immunosuppressive drugs. Viral vaccines prompt an immune response that lasts much longer than that elicited by classic antigen. Lack of distinction between the two kinds of responses may be why practitioners think titers can suddenly disappear.

    But, not all vaccines produce sterilizing immunity. Those that do include: distemper virus, adenovirus, and parvovirus in the dog, and panleukopenia virus in the cat. Examples of vaccines that produced non-sterile immunity would be leptospirosis, bordetella, rabies virus, herpesvirus and calicivirus --- the latter two being upper respiratory viruses of cats. While non-sterile immunity may not protect the animal from infection, it should keep the infection from progressing to severe clinical disease.

    Therefore, interpreting titers correctly depends upon the disease in question. Some titers must reach a certain level to indicate immunity, but with other agents like those that produce sterile immunity, the presence of any measurable antibody shows protection. The positive titer test result is fairly straightforward, but a negative titer test result is more difficult to interpret, because a negative titer is not the same thing as a zero titer and it doesn't necessarily mean that animal is unprotected. A negative result usually means the titer has failed to reach the threshold of providing sterile immunity. This is an important distinction, because for the clinically important distemper and parvovirus diseases of dogs, and panleukopenia of cats, a negative or zero antibody titer indicates that the animal is not protected against canine parvovirus and may not be protected against canine distemper virus or feline panleukopenia virus.

    Finally, what does more than a decade of experience with vaccine titer testing reveal ? Published studies in refereed journals show that 90-98% of dogs and cats that have been properly vaccinated develop good measurable antibody titers to the infectious agent measured. So, in contrast to the concerns of some practitioners, using vaccine titer testing as a means to assess vaccine-induced protection will likely result in the animal avoiding needless and unwise booster vaccinations.

    Our recent study (Twark and Dodds, 2000), evaluated 1441 dogs for CPV antibody titer and 1379 dogs for CDV antibody titer. Of these, 95.1 % were judged to have adequate CPV titers, and nearly all (97.6 %) had adequate CDV titers. Vaccine histories were available for 444 dogs (CPV) and 433 dogs (CDV). Only 43 dogs had been vaccinated within the previous year, with the majority of dogs (268 or 60%) having received a booster vaccination 1-2 years beforehand. On the basis of our data, we concluded that annual revaccination is unnecessary. Similar findings and conclusions have been published recently for dogs in New Zealand (Kyle et al, 2002), and cats (Scott and Geissinger, 1999; Lappin et al, 2002). Comprehensive studies of the duration of serologic response to five viral vaccine antigens in dogs and three viral vaccine antigens in cats were recently published by researchers at Pfizer Animal Health (Mouzin et al, 2004).
    When an adequate immune memory has already been established, there is little reason to introduce unnecessary antigen, adjuvant, and preservatives by administering booster vaccines. By titering triennially or more often, if needed, one can assess whether a given animal's humoral immune response has fallen below levels of adequate immune memory. In that event, an appropriate vaccine booster can be administered.
    Other Issues with Over Vaccination
    Other issues arise from over vaccination, as the increased cost in time and dollars spent needs to be considered, despite the well-intentioned solicitation of clients to encourage annual booster vaccinations so that pets also can receive a wellness examination. Giving annual boosters when they are not necessary has the client paying for a service which is likely to be of little benefit to the pet's existing level of protection against these infectious diseases. It also increases the risk of adverse reactions from the repeated exposure to foreign substances.

    Compliance or Resistence to Current Vaccine Guidelines ?
    For more than a decade, the issues discussed above on overvaccination and vaccine safety for companion animals have been raised by vaccinologists and veterinary clinicians. But, how has this still controversial knowledge impacted the veterinary profession and pet owner today? Have veterinarians really embraced the national policies on vaccination guidelines? Does the public trust veterinarians to be up-to-date on these issues or are they unsure? Do they believe veterinarians have a conflict of interest if they seek the income from annual booster vaccinations? Given media information regarding autism and measles vaccination, the public is more aware and worried about vaccine safety.
    Some veterinarians today still tell their clients there is no scientific evidence linking vaccinations with adverse effects and serious illness. This is ignorance, and confuses an impressionable client. On the other hand, vaccine zealots abound with hysteria and misinformation. None of these polarized views is helpful.

    Veterinarians are still routinely vaccinating ill dogs and those with chronic diseases or prior adverse vaccine reactions. This is especially problematic for rabies boosters, as many colleagues believe they have no legal alternative, even though the product label states it's intended for healthy animals. See www.rabieschallengefund.org

    New Breakthroughs
    Failure to standardize the legal mandate for rabies vaccinations nationwide is medically and scientifically unwarranted. The fact that individual states, counties and cities elect to mandate annual rabies boosters despite federally licensed three-year rabies vaccines is misguided.
    Now that Arkansa passed a new rabies law authorizing the State Health Department to establish rabies vaccination schedules which adopt a 3-year rabies protocol for dogs and cats (February 2009), Alabama just changed their rabies law to 3 years on August 1, 2009. However, some individual cities and counties still require annual rabies booster vaccination. For Cheyenne, WY and Wichita, KS, pressure from the public and the local veterinary associations effected a recent change to every three years.
    Despite these recent changes, the practice of rabies booster vaccination in these states and local areas has been left as optional at the discretion of the client's veterinarian. So this is a Catch-22 situation, because if the veterinarian still believes the rabies booster should be given annually instead of as licensed, they usually can talk their client into doing so.
    Rabies Vaccines and the USDA/CVB
    Rabies vaccines are the most common group of biological products identified in adverse event reports received by the USDA's Center for Veterinary Biologics (CVB). Currently, 14 rabies vaccines are labeled for use in dogs. These vaccines must meet the standard requirements established in the Title 9 Code of Federal Regulations. This requires that the vaccine provide a protected fraction of ? 83% when comparing vaccinated animals versus control animals. Also, all rabies vaccines are evaluated for safety prior to licensure, which includes performance of a field safety trial. Additionally, each serial of rabies vaccine is tested for potency by use of the National Institutes of Health potency test or another test approved by the CVB, and is tested for safety in the host and laboratory animals.

    Safety Review
    Before licensure, a product must be shown to be safe through a combination of safety evaluations. The field safety trial is the most comprehensive evaluation and has the objective of assessing the safety of the product in its target population under the conditions of its intended use. However, safety studies before licensure may not detect all safety concerns for a number of reasons, as follows: insufficient number of animals for low frequency events, insufficient duration of observation, sensitivities of subpopulations (eg, breed, reproductive status, and unintended species), or interactions with concomitantly administered products.

    State and Local Authority for Rabies Control Programs
    Although the CVB licenses veterinary biological products for use in the prevention of rabies, it is the state and local authorities govern and administer their respective rabies animal control programs. Some of these programs allow exemptions to the vaccination requirements, if medical concerns exist related to potential adverse events, but more commonly, others do not allow exemptions, regardless of the justification.

    Reporting Adverse Vaccine Reaction to Manufacturer and the Government
    There is no mandatory reporting of adverse reactions in veterinary medicine. The 2007 World Small Animal Veterinary Association (WSAVA) Vaccine Guidelines states that there is: "gross under-reporting of vaccine-associated adverse events which impedes knowledge of the ongoing safety of these products." WSAVA 2007 Vaccine Guidelines http://www.wsava.org/SAC.htm,
    Even in humans, where mandatory reporting of adverse vaccine reactions is required, Dr. David Kessler, former head of the Food & Drug Administration, reported that "only about 1% of serious events are reported to the FDA". [JAMA .269:.2785, 1993]. This problem of under-reporting has persisted for many years.
    Despite the serious under-reporting of vaccinal adverse reactions, the 2008 Report from the USDA's CVB [JAVMA 232:1000-1002, 2008], states that between April 1, 2004 and March 31, 2007, they "requested manufacturers of rabies vaccines to provide adverse event report summaries for their products. During this period, nearly 10,000 adverse event reports (all animal species) were received by manufacturers of rabies vaccines. Approximately 65% of the manufacturer's reports involved dogs."
    The USDA/CVB 2008 Report further states that "Rabies vaccines are the most common group of biological products identified in adverse event reports received by the CVB." During the 3-year period covered in this report, the CVB received 246 adverse event reports for dogs in which a rabies vaccine was identified as one of the products administered. Reports were assessed for causality, and of these,

    217 reports were considered possibly related to ? 1 of the vaccines given, 7 were considered unlikely, and 22 were assessed as unknown. Of reports with age information (n = 206), 21.4% of the dogs were ? 6 months old, 33.5% were > 6 months old but ? 2 years old, and 45.1% were > 2 years old. Of reports with sex information (n = 209), 54.5% of the dogs were female.

    The following clinical terms were listed ?to describe possibly related adverse events in dogs vaccinated against rabies? and reported to the USDA/CVB between April 1, 2004-March 31, 2007. For 217 adverse event reports ? the clinical term is followed by the % of dogs affected:
    Vomiting-28.1%; facial swelling-26.3%; injection site swelling or lump-19.4%; lethargy-12%; urticaria-10.1%; circulatory shock-8.3%; injection site pain-7.4%; pruritus-7.4%; injection site alopecia or hair loss-6.9%; death-5.5%; lack of consciousness-5.5; diarrhea-4.6%; hypersensitivity (not specified)-4.6%; fever-4.1%;, anaphylaxis-2.8%; ataxia-2.8%; lameness-2.8%; general signs of pain-2.3%; hyperactivity-2.3%; injection site scab or crust-2.3%;, muscle tremor-2.3%; tachycardia-2.3%; and thrombocytopenia-2.3%.

    The overall adverse report rate for rabies vaccines was determined to be 8.3 reports/100,000 doses sold. Adverse events considered possibly related to vaccination included acute hypersensitivity (59%); local reactions (27%); systemic reactions, which refers to short-term lethargy, fever, general pain, anorexia, or behavioral changes, with or without gastrointestinal disturbances starting within 3 days after vaccination (9%); autoimmune disorders (3%); and other (2%). In nearly 72% of the dogs of these reports, other vaccine or medicinal products were administered in conjunction with the rabies vaccine. In those instances, it was generally not possible to determine which product or products might be most closely linked to the adverse event. Additionally, in some instances, dogs had > 1 clinical sign, resulting in the coding of several clinical signs in a single report.

    But, IF one applied the only 1% estimated reporting figure of "serious" events from the former head of the FDA to the 10,000 adverse events reported for animal rabies vaccines, 65% of which were in dogs, then the actual number of dogs that had adverse reactions to the vaccine could be as high as 650,000 in that 3 year period with 3,575 (5.5%) of the dogs dying from their adverse reaction.

    Treatment of Vaccinosis
    The diagnosis of vaccinosis is an exclusionary one -- i.e. nothing will be found upon other testing to explain the symptoms. The animal is given the oral homeopathics, Thuja (for all vaccines other than rabies), and Lyssin to detox the rabies ?miasm?. IF there are no holistic veterinarians in the area, these homeopathics can be obtained from www.naturalrearing.com.

    Our therapy typically uses steroids in tapering doses over 4-6 weeks to stop the inflammatory process and clinical symptoms. Therapy begins with an injection of dexamethasone phosphate first, and if the animal improves right away, is continued with prednisone at 0.5 mg per pound twice daily for 5-7 days, then tapered gradually over the next month to every other day. The use of steroids will cause an increase in water intake and urination, but the animal should be able to handle the drug at these tapering doses for a few weeks. IF a holistic veterinarian wants to try an alternative therapy to steroids, this approach can also work. Try it for several days to see if it will work.

    We advise that these patients receive no further vaccine boosters, except for rabies, where exemption can be sought on a case-by-case basis but may not be granted in the specific locale.
    References

    ? Dodds WJ. More bumps on the vaccine road. Adv Vet Med 41:715-732, 1999.
    ? Dodds WJ. Vaccination protocols for dogs predisposed to vaccine reactions. J Am An Hosp Assoc 38: 1-4, 2001.
    ? Hogenesch H, Azcona-Olivera J, Scott-Moncreiff C, et al. Vaccine-induced autoimmunity in the dog. Adv Vet Med 41: 733-744, 1999.
    ? Hustead DR, Carpenter T, Sawyer DC, et al. Vaccination issues of concern to practitioners. J Am Vet Med Assoc 214: 1000-1002, 1999.
    ? Kyle AHM, Squires RA, Davies PR. Serologic status and response to vaccination against canine distemper (CDV) and canine parvovirus (CPV) of dogs vaccinated at different intervals. J Sm An Pract, June 2002.
    ? Lappin MR, Andrews J, Simpson D, et al. Use of serologic tests to predict resistance to feline herpesvirus 1, feline calicivirus, and feline parvovirus infection in cats. J Am Vet Med Assoc 220: 38-42, 2002.
    ? McGaw DL, Thompson M, Tate, D, et al. Serum distemper virus and parvovirus antibody titers among dogs brought to a veterinary hospital for revaccination. J Am Vet Med Assoc 213: 72-75, 1998.
    ? Moore GE, Glickman LT. A perspective on vaccine guidelines and titer tests for dogs. J Am Vet Med Assoc 224: 200-203. 2004.

    ? Moore et al, Adverse events diagnosed within three days of vaccine administration in dogs. J Am Vet Med Assoc 227:1102?1108, 2005.

    ? Mouzin DE, Lorenzen M J, Haworth, et al. Duration of serologic response to five viral antigens in dogs. J Am Vet Med Assoc 224: 55-60, 2004.
    ? Mouzin DE, Lorenzen M J, Haworth, et al. Duration of serologic response to three viral antigens in cats. J Am Vet Med Assoc 224: 61-66, 2004.
    ? Paul MA.Credibility in the face of controversy. Am An Hosp Assoc Trends Magazine XIV(2):19-21,1998.
    ? Paul MA (chair) et al. Report of the AAHA Canine Vaccine Task Force: 2003 canine vaccine guidelines, recommendations, and supporting literature. AAHA, April 2003, 28 pp.
    ? Paul MA (chair) et al. Report of the AAHA Canine Vaccine Task Force : 2006 AAHA Canine Vaccine Guidelines. J Am An Hosp Assoc 42:80-109, Mar-April 2006, 28 pp. www.aahanet.org
    ? Richards JR (chair) et al. The 2006 American Association of Feline Practitioners Feline Vaccine Advisory Report . J Am Vet Med Assoc 229:1405-1441, 2006. www.aafponline.org

    ? Schultz RD. Current and future canine and feline vaccination programs. Vet Med 93:233-254, 1998.
    ? Schultz RD, Ford RB, Olsen J, Scott F. Titer testing and vaccination: a new look at traditional practices. Vet Med, 97: 1-13, 2002 (insert).
    ? Scott FW, Geissinger CM. Long-term immunity in cats vaccinated with an inactivated trivalent vaccine. Am J Vet Res 60: 652-658, 1999.
    ? Scott-Moncrieff JC, Azcona-Olivera J, Glickman NW, et al. Evaluation of antithyroglobulin antibodies after routine vaccination in pet and research dogs. J Am Vet Med Assoc 221: 515-521, 2002.
    ? Smith CA. Are we vaccinating too much? J Am Vet Med Assoc 207:421-425, 1995.
    ? Tizard I, Ni Y. Use of serologic testing to assess immune status of companion animals. J Am Vet Med Assoc 213: 54-60, 1998.
    ? Twark L, Dodds WJ. Clinical application of serum parvovirus and distemper virus antibody titers for determining revaccination strategies in healthy dogs. J Am Vet Med Assoc 217:1021-1024, 2000.
    ? Vascellari M, Melchiotti E, Bozza MA et al. Fibrosarcomas at presumed sites of injection in dogs: characteristics and comparison with non-vaccination site fibrosarcomas and feline post-vaccinal firosarcomas. J Vet Med 50 (6): 286-291, 2003.

    CANINE VACCINE ADVERSE EVENTS *
    ? retrospective cohort study; 1.25 million dogs vaccinated at 360 veterinary hospitals
    ? 38 adverse events per 10,000 dogs vaccinated
    ? inversely related to dog weight
    ? vaccines prescribed on a 1-dose-fits-all basis, rather than by body weight.
    ? increased for dogs up to 2 yr of age, then declined
    ? greater for neutered versus sexually intact dogs
    ? increased as number of vaccines given together increased
    ? increased after the 3 rd or 4 th vaccination
    ? genetic predisposition to adverse events documented
    _____________________________________________________________
    * from Moore et al, JAVMA 227:1102?1108, 2005

    VACCINE CONCLUSIONS FOR CANINES *
    Factors that increase risk of adverse events 3 days after vaccination:

    ? young adult age
    ? small-breed size
    ? neutering
    ? multiple vaccines given per visit
    These risks should be communicated to clients
    _______________________________________________________
    * from Moore et al, JAVMA 227:1102?1108, 2005

    FELINE VACCINE ADVERSE EVENTS *
    ? retrospective cohort study; 0.5 million cats vaccinated at 329 veterinary hospitals
    ? 51.6 adverse events per 10,000 cats vaccinated
    ? inversely related to cat weight
    ? increased for cats about 1 yr of age
    ? greater for neutered versus sexually intact cats
    ? increased as number of vaccines given together increased
    ? Lethargy with or without fever was most common sign
    _________________________________________________
    * from Moore et al, JAVMA 231:94-100, 2007

    VACCINE CONCLUSIONS FOR FELINES *
    Factors that increase risk of adverse events 30 days after vaccination:
    ? young adult age
    ? neutering
    ? multiple vaccines given per visit
    These risks should be communicated to clients, and the number
    of vaccines administered concurrently limited
    _______________________________________________________
    * from Moore et al, JAVMA 231:94-100, 2007
  • Reply
    Teresa Dec 7, 2011 @ 10:01 pm | delete
    I gave my German shepherd the rabies vaccine. She became aggressive toward other dogs and foamed at the mouth during walks. I did not the it to the vaccine until I gave her her next vaccine at five years old and within one week, she visciously attacked my four year old child. I think she would ave killed my child if I had not been there. So sad as they had grown up together. Thankfully my child has recovered but we had to euthanize the other member of the family. Damn rabies vaccine.
  • Reply
    Cindy Bell Nov 25, 2011 @ 9:09 am | delete
    Dear Jan, Thank you so much for all that you are doing to get the work out. I love your video, but found it too late for our male dog. He died in one week after a rabies vaccine given to him by the Vet who gave him a clean bill of health prior to administering the vaccine last Tuesday. He was not eating by Sunday night, and was no longer his bouncing, bubbly self. So Monday when we took him to the vet to have the lack of appetite, and energy noted in his file, we were shocked to hear that his red blood cell count was at 17, and he was on deaths door. His gums were yellow and he began to urinate blood! The vet gave him steroids to boost his immune system, and a blood transfusion to hold him over until the meds could kick in. He said the transfusion we will generally see an increase in red blood cells, but Toby's levels dropped to 10. So on Tuesday morning he was given another blood transfusion and again continued to fail! By Tuesday eve the vet said Toby was totally unresponsive and if he should improve at that point (to which he said was slim to none)? he would never be the same. It gave us no choice but to put him down. He never leaves our sight, or our fenced yard, (Except for his shots) He eats home made food. His white blood cell count was good, and the vet said there was no internal bleeding. We can not come up with any other explanation for his sudden death other then the rabies vaccine last Tuesday! Our female did not get the shot and she is fine! Our vet never told us that there is a test to see if they really need the vaccine, or that you can request it without mercury! I was shocked to realize there are worse side effects then death!
    A woman just posted that her vaccinated dog just killed her other dog 4 days after a Rabies vaccine! She said the dogs had been together for years without any problems.
    She may have to have the vaccinated dog put down, if she has small children in the house, so she may lose both dogs in a heart beat!
    I like most people, work full time and do not have the time to fight for my dogs rights. I read that the reaction should be reported to the drug company by our Vet, and when telling the vet what I read, he asked me to send him the link? So it seems he is not aware or ever plans to report side effects to anyone!
  • Reply
    Michelle Nov 4, 2011 @ 3:45 pm | delete
    My cat was sterilised and given the rabies vaccine straight after by the vet when she was still poor after the surgery. She was even given 2 other vaccines at same time. 2 hrs later she died in my arms after vomiting the night before and slowly becoming paralysed. The last stage happened very quickly. I did not know that you shouldn't give the vaccine after surgery I trusted the vet that he knew what he did, and that you should not combine vaccines but when I read this article I feel more assure that the vet did wrong. No words can explain the heartbreak i feel as I think this vet acted extremely irresponsible.
  • Reply
    Dog_Guy Oct 13, 2011 @ 1:38 am | delete
    you brought up a couple of points very few people know - that cats can get rabies and that it is supposed to be extinct in 2007. I guess thats why they still make it compulsory but of course that doesnt include stray dogs. Thanks for the information!
  • Reply
    TheGourmetCoffeeGuy Oct 9, 2011 @ 3:14 am | delete
    Very good information, interesting lens, deal with the vaccination matter yearly for our Siberian Huskies and it is a concern but a requirement to do as responsible dog owners. Thankfully, have not had to deal with serious reactions or emergencies. thank you for sharing. your insights.
  • Reply
    Kristen Sep 22, 2011 @ 12:55 pm | delete
    My now 10yr old lab had 1st booster shot along with rabies shot in 2003 and then again had booster along with rabies shots on Aug 27th 2004. Well in Oct 7 2004 she developed chronic ear infections along with itchiness and licking hot spots. Vet told me she had allergies. She has gotten progressively worse to the point of extreme hair loss and scaly black crusty skin mainly on her whole belly. Feel very bad for her. I've tried everything but nothing seemed to help. I never even thought that her vaccinations could have caused this problem. Now I know why there are so many dog food products coming out on the market for dogs labelled with allergies.

    Just brough home another lab puppy. The breeder gave her first booster, but that is all she will be getting. Even though the vets tell me how labs are prone to so many health problems including allergies...ya right
  • Reply
    profilesincolor Jun 28, 2011 @ 3:41 pm | delete
    Thoughtful lens. Thanks for sharing!
  • Reply
    AMK Jun 25, 2011 @ 2:07 am | delete
    found this squid via google. did not even search on squidoo so thats good for you to know! otherwize: my belgian shepherd got the rabies vacination last week and he vomited all day. he even became over agressive to strangers. Now he seems fine although eats less? Vet says its not the vacination, but I am inclined to disagree since he is normaly a very calm dog for the groendahl breed.
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K9Author

Hi. I'm Jan Rasmusen, author, newsletter writer, dog health and safety advocate. After my Maltese Jiggy was diagnosed with life-threatening immune-mediated... more »

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