Scooby-Doo is a long-running American animated series produced for Saturday morning television in several different versions from 1969 to the present. The original series, Scooby-Doo, Where Are You!, was created for Hanna-Barbera Productions by writers Joe Ruby and Ken Spears and character designer, Iwao Takamoto. Hanna-Barbera produced numerous spin-offs and related works until being absorbed in 1997 into Warner Bros., which has handled production since then. Although the format of the show and the cast (and ages) of characters have varied significantly over the years, the most familiar versions of the show feature a talking dog named Scooby-Doo and four teenagers: Fred "Freddie" Jones, Daphne Blake, Velma Dinkley, and Norville "Shaggy" Rogers.

These five characters (officially collectively known as "Mystery, Inc.", but never referred to as such in the original series) drive around the world in a van called the "Mystery Machine", and solve mysteries typically involving tales of ghosts and other supernatural forces. At the end of each episode, the supernatural forces turn out to have a rational explanation, typically criminal plots involving costumes and special effects intended to frighten or distract. Later versions of Scooby-Doo featured different variations on the show's supernatural theme, and include characters such as Scooby's cousin Scooby-Dum and nephew Scrappy-Doo in addition to or instead of some of the original characters.

Scooby-Doo was originally broadcast on CBS from 1969 to 1976, when it moved to ABC. ABC aired the show until canceling it in 1986, and presented a spin-off, A Pup Named Scooby-Doo, from 1988 until 1991. A new Scooby-Doo series, What's New, Scooby-Doo?, aired on the WB Network during the Kids' WB programming block from 2002 until 2005. The current Scooby-Doo series, Shaggy & Scooby-Doo Get a Clue!, airs Saturday mornings on The CW network. Repeats of the original series, as well as second-run episodes of What's New, Scooby-Doo?, are broadcast frequently on the Cartoon Network and Boomerang in the United States and other countries.

Scooby-Doo, Where Are You! made its CBS network debut on Saturday, September 13, 1969 with its first episode, "What a Night for a Knight". The original voice cast featured Don Messick as Scooby-Doo, Casey Kasem as Shaggy, Frank Welker as Fred, Nicole Jaffe as Velma, and Stefanianna Christopherson as Daphne. Seventeen episodes of Scooby-Doo were produced in 1969. The series' eponymous theme song was written by David Mook and Ben Raleigh, and performed by Larry Marks.

In 2002, following the successes of the Cartoon Network reruns and four late-1990s direct-to-video Scooby-Doo releases, the original version of the gang was updated for the 21st century for What's New, Scooby-Doo?, which aired on Kids' WB from 2002 until 2005, with second-run episodes also appearing on Cartoon Network. Unlike previous Scooby series, the show was produced at Warner Bros. Animation, which had absorbed Hanna-Barbera in 2001. The show returned to the familiar format of the original series for the first time since 1978, with modern-day technology and culture added to the mix to give the series a more contemporary feel, along with new, digitally-recorded sound effects and music. With Don Messick having died in 1997, Frank Welker took over as Scooby's voice actor, while continuing to provide the voice of Fred as well, and Casey Kasem returned as Shaggy. Grey DeLisle provided the voice of Daphne (she first took the role on Scooby-Doo and the Cyber Chase, replacing Mary Kay Bergman, who committed suicide shortly before the release of Scooby-Doo and the Alien Invaders) and former Facts of Life star Mindy Cohn voiced Velma.