Star Trek Online Crafting Guide

At level four, you can get a quest from Lt. Commander E'Genn, located in the center of Earth Spacedock, asking you to take a sample to Commander Jenna Romaine at Memory Alpha. Deliver this sample to her, and leave it on the table nearby (by the ramp closest to the transporter room), as your introduction to her and the upgrade system (most commonly called crafting, because that's what it's most like although it's not precisely accurate).

At this point you can access her Store option to see what you can upgrade and how many samples it takes. Samples you don't have enough of and items you don't possess are displayed as red.

As the other scientists say, you have to craft with her before other scientists will be unlocked. For most players, crafting about 7000 credits worth of gear unlocks Tier 2. There appears to be an element of chance, or something we haven't pinned down yet, as this general rule doesn't work for everyone. Some players report that they had to upgrade more gear. My Tier 2 has unlocked (on all my characters) by putting Critical Severity bonuses on exactly 5 phaser beam array Mk IIs.

Tier 3 is more complicated. Trade with the Tier 2 scientist in the same room as the Tier 3 scientist you want to unlock, in order to unlock T3. Again, there are reports that the amounts vary for players, but for many, Tactical Tier 3 unlocks at approximately 100,000 credits worth and Science and Engineering at around 350,000 to 450,000 credits.

All of these totals are the retail price of the final item, not the price of supplies.

Anomalous Readings are lootable spots on mission maps. They come in three types and produce a variety of samples. The grade of sample that appears depends on your level. Grade 1 begins to appear at level 1, Grade 2 at level 5, Grade 3 at level 10, Grade 4 at level 15, Grade 5 at level 20, and Grade 6 at level 25.

Here are the types and the samples you can obtain from them, in order of grade:

Anomalous Energy Readings:
1 - Radiation Sample
2 - Antimatter Sample
3 - Tetryon Particle
4 - Methogenic Particle
5 - Tachyon Wave Signature
6 - Chronometric Wave Signature

Anomalous Physical Readings:
1 - Mineral Sample
2 - Biological Sample
3 - Plasma Sample
4 - DNA Sequence
5 - Exobiological Data
6 - Unidentified Substance

Anomalous Technological Readings:
1 - Alien Artifact
2 - Unknown Alloy
3 - Encoded Data
4 - Genetic Sequencer
5 - Photonic Technology
6 - Technical Schematic

Commander Romaine is the Tier 1 scientist. You work your way up to the next tier by crafting. Grinding out a bunch of hypos and power cells is not the most efficient way to unlock the next tier, as total overall value of the items made seems to be the key factor. At this point, there's no notification you've achieved the next tier. You have to discover this yourself by talking to that tier's scientists.

Tier 1 upgaded items are green uncommons. Tier 2 and Tier 3 upgraded items are all blue rarity.

Tier 1 Item Upgrades Sold:
* Large Hypo
* Large Power Cell
* Personal Shield Mk II
* Disruptor Bolt Dual Pistol - Sweep Mk II
* Phaser Beam Pistol - Wide Beam Mk II
* Phaser Beam Array Mk II
* Photon Torpedo Launcher Mk II
* Engineering Kit - Basic Explosives Mk II
* Science Kit - Medic Mk II
* Tactical Kit - Basic Grenades Mk II

Tier 2
Lt. Commander Anichent:
* Plasma Bolt Assault Weapon - Energy Blast Mk IV
* Plasma Bolt Pistol - Compression Bolt Mk IV
* Plasma Bolt Rifle - Sniper Rifle Mk IV
* Plasma Beam Array Mk IV
* Plasma Dual Cannons Mk IV
* Plasma Torpedo Launcher Mk IV
* Quantum Torpedo Launcher Mk IV
* Tactical Kit - Close Combat Specialist Mk IV
* Tactical Kit - Fire Team Mk IV

Zara Dren:
* Personal Shield Mk IV
* Plasma Beam Pistol
* Deflector Array Mk IV
* Deflector Array Mk IV
* Deflector Array Mk IV
* Covariant Shield Array Mk IV
* Science Kit - Physician Mk IV
* Science Kit - Analyst Mk IV

Ensign Marissa Roet:
* Body Armor - Energy Dampening Mk IV
* Body Armor - Pollyalloy Wave Mk IV
* Personal Shield Mk IV
* Personal Shield Mk IV
* Combat Impulse Engines Mk IV
* Hyper-Impulse Engines Mk IV
* Impulse Engines Mk IV
* Engineering Kit - Enemy Neutralization Mk IV
* Engineering Kit - Support Technician IV

Tier 3
Lt Kirayoshi O'Brien, Engineering:
* Personal Shield Mk VIII & Mk X
* Body Armor - Energy Dampening Mk VIII & Mk X
* Body Armor - Pollyalloy Weave Mk VIII & Mk X
* Impulse Engines Mk VIII & Mk X
* Hyper-Impulse Engines Mk VIII & Mk X
* Combat Impulse Engines Mk VIII & Mk X
* Engineering Kit - Enemy Neutralization Mk VIII & Mk IX
* Engineering KIt - Bunker Fabrication Mk VIII & Mk IX

Commander Jher Gwenn, Science:
* Personal Shield Mk VIII & Mk X
* Tetryon Beam Pistol - Stun Beam Mk VIII
* Deflector Array Mk VIII & X
* Covariant Shield Array Mk VIII & Mk X
* Polaron Beam PIstol - Stun Beam Mk IX
* Science Kit - Physician Mk VIII & IX
* Science Kit - Analyst Mk VIII & IX

Commander Shann, Tactical:
* Tetryon Bolt Assault Weapon - Energy Blast Mk VIII
* Tetryon Bolt Pistol - Compression Bolt MK VIII & Mk X
* Tetryon Bolt Rifle - Sniper Rifle Mk VIII
* Tetryon Beam Array Mk VIII
* Tetryon Dual Cannons Mk VIII
* Transphasic Torpedo Launcher Mk VIII & Mk X
* Polaron Bolt Assault Weapon - Energy Blast Mk X
* Polaron Bolt Rifle - Sniper Rifle Mk X
* Polaron Dual Cannons Mk X
* Polaron Beam Array Mk X
* Chroniton Torpedo Launcher Mk VIII & Mk X
* Tactical Kit - Grenade Satchel Mk IX & Mk XIII
* Tactical Kit - Operative MK VIII & IX