Naturally Increase the Number of Stem Cells Circulating in your Body

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1 year 7 months ago, my life changed dramatically as the result of a serious car accident. Like thousands of others in our nation, I now face life as a paraplegic. Today, because of outstanding research and development; supplements, equipment, medication all exists today which can give hope and promise to others like me to achieve the reults of walking again some day. Since my accident I have focused much of my time to research, trial and use any which will provide me with the BEST chance to reach my goal - To some day WALK! Read the Actually Journal Click here
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We are talking about and botanical extract called AFA that supports wellness by helping your body maintain healthy stem cell physiology. This is the very first product in this new category call "Stem Cell Enhancers". Recent scientific developments have revealed that stem cells derived from the bone marrow travel through the body and repair, renew, and rejuvenate, damaged cells. Adult Stem Cells are the master cells of the body and can become brain, liver, muscles, nerve, tissue cells and more. When you take two capsules of StemEnhance you increase the number of stem cells in the blood stream by 3 to 4 million. Doing this on a daily basis will improve your health and tilt the balance of your system to a healthier improved wellness. All this has been proven by Scientist and Medical Teams view reports.
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SCIENCE UPDATE: The New England Journal of Medicine stated that the number one indicator of anyone's wellness is directly correlated to the number of adult stem cells in the blood stream.

Adult Stem Cells - An Exciting New Paradigm in Health
The discovery that Bone Marrow Stem Cells constitute the natural renewal system of the body has paved the way to a new paradigm in health and wellness. In fact, a number of recent studies have shown that a greater number of circulating adult stem cells equated to greater cardiovascular and over all better health.
StemTech Health Sciences, Inc., a pioneer in development and marketing, introduced the first natural dietary supplement proven to support the release of adult stem cells into circulation. This ground breaking discovery started as a theory in the mind of research scientist Christian Drapeau MSc.
After accumulating many years of experience observing the health benefits which came from the aqua-botanical Aphanizomenon flos-aquae, (AFA) he began intensive research, along with his colleague Dr. Gitte Jensen. This research led to a very intriguing theory involving adult stem cell physiology and how isolated extracts of the aqua-botanical AFA, seemed to support and enhance the natural behavior of adult stem cells in the body.
Enter "adult stem cell enhancers" a powerful new category of nutritional supplements. Introduced in 2005, StemEnhance® is the World's first and only clinically proven adult stem cell enhancer on the market. StemEnhance® is a patented concentrate of Aphanizomenon flos-aquae (AFA). The results are impressive to say the least.
As shown in a double-blind placebo controlled crossover study published in the highly respected peer-reviewed journal, Cardiovascular Revascularization Medicine (Aug-Sept 2007), taking just 2 capsules of StemEnhance® supports an average 25% increase in the number of naturally released adult stem cells.

That is equivalent to about 3 to 4 million new adult stem cells in circulation - making StemEnhance® one of the greatest wellness discoveries of our time!
How can such a discovery have been so long in coming? Thanks to the discovery of a spontaneously fluorescent protein called green fluorescent protein (GFP) which was isolated from the deep ocean jelly fish Aequoria victoria. Since GFP is a protein, it is possible to derive the DNA responsible for its production and to incorporate the GFP-gene in the nucleus of a stem cell. In such a case, all the cells derived from the original fluorescent stem cell will be fluorescent. The discovery of GFP is of such importance that the scientists responsible for the discovery were actually awarded the 2008 Nobel Prize in chemistry.
Thanks to the discovery of GFP, adult stem cells from the bone marrow have been shown to have the ability to naturally become, but not limited to, cells of the liver, muscle, retina, kidney, pancreas, lung, skin, and even the brain.
Current scientific studies show:
%u2022 Mobilization of bone marrow stem cells with StemEnhance® improves muscle regeneration in cardiotoxin-induced muscle injury
%u2022 StemEnhance® improves physical performance of weight training in non-professional participants
%u2022 Increase in the number of circulating stem cells by StemEnhance® does not promote tumor growth
%u2022 Daily consumption of StemEnhance® helps reduce hair graying
These studies have enormous implications because through the body's natural mechanisms, stem cells circulate to areas where they are needed to support the natural renewal process. By giving rise to an increase in circulating adult stem cells, StemEnhance® supports the body's natural ability to rebuild, renew, and rejuvenate.
The implications are significant - StemEnhance®, when used as a daily supplement, supports the release of millions of additional adult stem cells in the bloodstream which is one of the most important ways for maintaining optimal health that science has yet discovered!
For more information on the AFA concentrate, go to the following website: www.adultstemcellsrelease.com

Disclaimer: This information contained in this article is for educational purposes only and does not constitute medical advice. The opinions expressed herein are those of the author and any product mentioned, while supported by science, is not intended to diagnose, treat, cure, or prevent any disease.

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CARDIOVASCULAR REVASCULARIZATION MEDICINE
SCIENTIFIC STUDIES

CARDIOVASCULAR REVASCULARIZATION MEDICINE
including Molecular Interventions
Posted January 1, 2008

Abstract - PubMed.gov

Description

Mobilization of human CD34+CD133+ and CD34+CD133%u2212 stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae-related to modulation of CXCR4 expression by an L-selectin ligand?

This article is not included in your organization's subscription. However, you may be able to access this article under your organization's agreement with Elsevier.
Gitte S. Jensen, Aaron N. Hartb, Lue A.M. Zaske, Christian Drapeau, Niraj Guptad, David J. Schaeffere and J. Alex Cruickshank

a. Holger NIS, 601 13 Avenue NE, Calgary, Alberta, Canada T2E 1C7
b. NIS Labs, 1437 Esplanade, Klamath Falls, OR, USA
c. StemTech Health Sciences Inc., 1011 Calle Amanecer, San Clemente, CA, USA
d. Cancer Treatment Center, Merle West Medical Center, 2610 Uhrmann Rd, Klamath Falls, OR, USA
e. Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, USA

The co author C. Drapeau is Chief Science Officer for StemTech Health Sciences, which distributes the product StemEnhance, used for the in vivo part of this paper. No other authors have any commercial interest in the subject matter.
Available online 29 August 2007.

ABSTRACT

OBJECTIVE

The goal of this study was to evaluate effects on human stem cells in vitro and in vivo of an extract from the edible cyanobacterium Aphanizomenon flos-aquae (AFA) enriched for a novel ligand for human CD62L (L-selectin).

EXPERIMENTAL APPROACH

Ligands for CD62L provide a mechanism for stem cell mobilization in conjunction with down-regulation of the CXCR4 chemokine receptor for stromal derived factor 1. Affinity immunoprecipitation was used to identify a novel ligand for CD62L from a water extract from AFA. The effects of AFA water extract on CD62L binding and CXCR4 expression was tested in vitro using human bone marrow CD34+ cells and the two progenitor cell lines, KG1a and K562. A double-blind randomized crossover study involving 12 healthy subjects evaluated the effects of consumption on stem cell mobilization in vivo.

RESULTS

An AFA extract rich in the CD62L ligand reduced the fucoidan-mediated externalization of the CXCR4 chemokine receptor on bone marrow CD34+ cells by 30% and the CD62L+ CD34+ cell line KG1A by 50% but did not alter the CXCR4 expression levels on the CD34* cell line K562. A transient, 18% increase in numbers of circulating CD34+ stem cells maximized 1 hour after consumption (P <.0003). When 3 non compliant volunteers were removed from analysis, the increase in CD34+ cells was 25% (P<.0001).

CONCLUSION

AFA water extract contains a novel ligand for CD62L. It modulates CXCR4 expression on CD34+ bone marrow cells in vitro and triggers the mobilization of CD34+ CD133+ and CD34+ CD133* cells in vivo.

Keywords: L-selectin; Ligand; Human; Adult stem cell; CD34; CD133; KG1a; K562; Bone marrow; Mobilization; Blue-green algae; Cyanobacteria; Aphanizomenon; In vivo; In vitro

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Peer Review Study

Olimpio Franceschi, Puerto Rico
When Olimpio first heard about STEMTech, it was from his doctor and friend, Enrique Martinez, whose help Olimpio had sought for a very uncomfortable problem with his jaw. "I couldn't open my mouth for three days," he explains. Having just returned from STEMTech's Launch Celebration in California, Dr. Martinez knew just what to suggest - StemEnhance. With the first capsules, Olimpio felt "something was going on." By the next afternoon, his discomfort was gone and he could enjoy a meal again. Soon Olimpio noticed that other physical challenges that had kept him from enjoying life to the fullest were diminishing. His wife Annie began taking the
product too, and soon she was once again able to climb stairs, which had been impossible to her for years. "I saw these results, and I knew I had to take the StemEnhance message to others," he explains. He became an Embajadores de la Salud (Health Ambassador) and began traveling all over the island of Puerto Rico sharing StemEnhance. "I learned that not only could I deliver health to the people of my country, but also I could make a good income for my family," he says. Olimpio's climb up the STEMTech ladder has been steady and very rapid. Each month he moved up a level, making Double Diamond after only seven months in business. For Olimpio, the STEMTech business is simple. "I talk to people about the benefits of good health, and then I suggest they take StemEnhance and let their bodies talk to them. Once they see what StemEnhance does for them, they want to tell everyone about it!"

Deborah Sanders, Florida
"For many years, I was never fully asleep at night or fully awake during the day,"Deborah says. Her troublesome physical challenges curtailed any hope she may have had to lead a "normal" life. She became depressed and stayed away from people. "I suffered a lot of abuse from people who didn't understand my situation. They just assumed I was on prescription drugs or something," she says. Last December, Deborah began taking StemEnhance. "Within a few hours, I began to feel strange. I was suddenly aware of my surroundings, crystal clear," she says. "It was almost frightening!" Deborah says that over the next few days it was as though her mind had "awakened." That night she went to bed and got up the next morning to a surprise. "I was awake, completely awake, and I stayed awake and alert all day!" Deborah couldn't believe it. "I had been partially asleep for 22 years I felt like I had gotten my life back," she says. Deborah began calling people to share the good news. "Many people had never seen me really awake and alert," she says ruefully. "But when they came over to the house and saw the change in me, they wanted to know how I did it. I started handing out the StemEnhance Story DVDs and people started signing up." Deborah says it has all been like a dream -- in a good way. "I feel like I've gone from rags to riches. I am awake and I am happy. Thank you, StemEnhance"

Laurie Powers, Michigan
A professional photographer, Laurie Powers was just coming out of her busy season when she began to notice a sudden change in her vision and a prickly sensation in her arms. "Something's not right," she thought. Medical tests were inconclusive with the doctors saying she "might" be facing a long-term physical challenge. When they suggested a regimen of shots, Laurie's stress level went through the roof. She opted out of further treatment and went home to think. "I called my friends and asked for their prayers," Laurie says. "My energy was gone. I was scared, and I didn't know what was happening to me." Then one of her mother's friends suggested she should try a new product called StemEnhance.
Laurie checked the STEMTech web site and was so intrigued by the science behind this breakthrough product that she ordered a bottle. "Within two days of taking my first capsules my energy was up and my stress level was way down," Laurie says. Since then, my troubling symptoms have been going away and I am feeling really good again. I thank StemEnhance for helping my body to maintain optimal health.

INTRODUCTION
THE EDIBLE CYANOPHYTA Aphanizomenon flos-aquae is known for its bioavailable antioxidants, including phycocyanin, immunomodulatory polysaccharides, and a beneficial lipid profile. We have previously reported that
ingestion of A. flos-aquae results in rapid and transient homing of natural killer (NK) cells in vivo. The current study was undertaken to explore several mechanisms that may contribute to an induction of NK cell trafficking and activation. NK cells play a key role in immune surveillance and the primary defense against viral infections and cancer, as they are capable of killing virally infected cells and some tumor cells without prior sensitization. NK cells also contribute to the defense against some bacteria. This involves prior phagocytosis of bacteria by macrophages followed by contact between macrophages and NK cells. RNAs for Tolllike receptor (TLR) 1-6 and TLR9 are expressed in circulating NK cells, allowing NK cells to respond to various bacterial cell wall components, including peptidoglycans and lipopolysaccharides, as well as bacterial DNA. Dietary intervention for enhancement of immune surveillance and primary defense includes nutritional support of a healthy composition of the gut flora. Commensal organisms in the gut, including lactobacilli, have been found to possess potent NK-activating properties. This property extends to fixed cells and isolated cell wall fractions of the commensal organisms.
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Aaron N. Hart, Lue Ann Zaske, Kelly M. Patterson, Christian Drapeau, and Gitte S. Jensen

NIS Labs, Klamath Falls; Desert Lake Technology LLC, Keno, Oregon; and Holger NIS, Calgary, Alberta, Canada

ABSTRACT
The present research was designed to study the effects of an extract from the edible cyanophyta Aphanizomenon flos-aquae on human natural killer (NK) cells. We have previously shown, using a double-blind randomized placebo-controlled crossover design, that ingestion of 1.5 g of dried whole A. flos-aquae resulted in a transient reduction in peripheral blood NK cells in 21 healthy human volunteers, suggesting increased NK cell homing into tissue. We have now identified an extract from A. flos-aquae (AFAe) that directly activates NK cells in vitro and modulates the chemokine receptor profile. NK cell activation was evaluated by expression of CD25 and CD69 on CD3CD56 cells after 18 hours. Changes in CXCR3 and CXCR4 chemokine receptor expression after 5-60 minutes were evaluated by immunostaining and flow cytometry. AFAe induced the expression of CD69 on CD3 CD56 NK cells, induced CD25 expression on 25% of these cells, and acted in synergy with interleukin 2. NK cells enriched by RosetteSep® (StemCell Technologies Inc., Vancouver, BC, Canada) were
not activated by AFAe, indicating that the NK activation was dependent on other cells such as monocytes. The low-molecular-weight fraction <5,000 of AFAe was responsible for the most robust NK cell activation, suggesting novel compounds different from previously reported macrophage-activating large polysaccharides.

KEY WORDS: . Aphanizomenon flos-aquae .blue-green algae . human . immunomodulation . low-molecularweight .peptides . trafficking

INTRODUCTION

THE EDIBLE CYANOPHYTA Aphanizomenon flos-aquae is known for its bioavailable antioxidants, including phycocyanin, immunomodulatory polysaccharides, and a beneficial lipid profile. We have previously reported that ingestion of A. flos-aquae results in rapid and transient homing of natural killer (NK) cells in vivo. The current study was undertaken to explore several mechanisms that may contribute to an induction of NK cell trafficking and activation.

NK CELLS PLAY a key role in immune surveillance and the primary defense against viral infections and cancer, as they are capable of killing virally infected cells and some tumor cells without prior sensitization. NK cells also contribute to the defense against some bacteria. This involves prior phagocytosis of bacteria by macrophages followed by contact between macrophages and NK cells. RNAs for Toll-like receptor (TLR) 1-6 and TLR9 are expressed in circulating NK cells, allowing NK cells to respond to various bacterial cell wall components, including peptidoglycans and lipopolysaccharides, as well as bacterial DNA.

DIETARY INTERVENTION for enhancement of immune surveillance and primary defense includes nutritional support of a healthy composition of the gut flora. Commensal organisms in the gut, including lactobacilli, have been found to possess potent NK-activating properties. This property extends to fixed cells and isolated cell wall fractions of the commensal organisms.

CONSUMPTION of CYANOBACTERIA as dietary supplements presents interesting possibilities in terms of NK cell activation. Cyanobacteria are primitive organisms resembling bacteria as well as chloroplasts and are thought to represent organisms that gave rise to chloroplasts. They share molecular similarities with bacteria, including bacterial DNA and cell wall omponents such as peptidoglycans, which are known to induce NK cell activation. In addition, the outer cell wall represents carbon storage and consists of large complex polysaccharides with immunomodulatory activity and may contribute to the ocumented antiviral and anti-cancer effects of some blue-green algae. Consumption of edible cyanobacteria may thus present similar compounds to the immune system as some commensal gut bacteria.

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