Stem cells have the remarkable potential to develop into many different cell types in the body. Serving as a sort of repair system for the body, they can theoretically divide without limit to replenish other cells as long as the person or animal is still alive.

When a stem cell divides, each new cell has the potential to either remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell.

This document covers basic information about stem cells. For a more detailed discussion, see our Stem Cell Reports. Or you can check the Frequently Asked Questions page for quick answers to specific queries.

Introduction
What are the unique properties of all stem cells?
What are embryonic stem cells?
What are adult stem cells?
What are the similarities and differences between embryonic and adult stem cells?
What are the potential uses of human stem cells and the obstacles that must be overcome before these potential uses will be realized?
Where can I get more information?

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Modern science has proven that stem cells are essentially the building blocks of our body. Additionally, science has shown that adult stem cells are found in most organs, tissue, and especially bone marrow. These cells are pre-programmed to migrate toward problem areas within the body and begin a repair process.

However, as our bodies age, adult stem cell production and efficacy lessen, and we in turn become more prone to illness or injury, which is commonly referred to as aging!

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Treating Diseases

Q: Which diseases could be treated with stem cells?

A: Theoretically, virtually any disease could be treated by stem cells. Every disease that we know of happens because cells in the body either are not functioning right or because they are overwhelmed. For instance, after a heart attack, the muscle cells in the heart are not working properly, and if they were replaced by normally functioning cells, your heart would be as good as new. In other diseases, your body has the ability to cure itself but it is overwhelmed. Stem cells can be used to create the cells in the body that are responsible for fighting these diseases and then putting them in the body -- the same way an army commander may send in reinforcements to a help a unit that is in danger of losing a battle.

As a matter of fact, scientists may be able to pick the right set of stem cells and make them grow into an organ like the liver or the kidneys. That way, they could generate a lot of replacement organs that could be used for organ transplants when they are needed.

It is important to keep in mind that these are still possibilities. Until a lot more research is done on the subject, we cannot be sure.

"It sounds easier than it is," Dominguez-Bendala says.

"Normally, the approach that we are following is not to reinvent the wheel but rather look at how nature does it," he says.

"If you put things in a Petri dish, that's a very simple way of culturing the cells. If you think about how they develop in the real embryo, that's an exquisitely complicated environment. So we need to … mimic the biological niche where they develop," Dominguez-Bendala says.

Examples of the kind of research that is being done using stem cells include:

• Diabetes: Scientists are trying to get stem cells to turn into insulin-producing cells that could then be put inside the body of a person with diabetes.


• Parkinson's disease: In Parkinson's disease, specific nerve cells in the brain are not working properly. If those cells can be created out of stem cells, they can be used to replace the diseased cells.


• Heart disease: After a heart attack, a portion of the heart muscle dies. Scientists are trying to get stem cells to make heart muscle cells that would replace the damaged part of the heart.


• Cancer: In many cancers, like breast cancer, treatments like chemotherapy and radiation can destroy the bone marrow. By using stem cells to recreate the bone marrow, doctors could use more powerful treatments to treat the cancer. Stem cells could also be used to create specific cells that could kill the cancer. If an organ or a chunk of tissue has to be removed or destroyed to get rid of the cancer, stem cells could be used to replace it.


• Spinal cord injury: Stem cells have been used to make the nerve cells in the spinal cord. This may help or even cure people who have lost use of their arms or legs because of an injury to their spinal cord.


• Crohn's disease: This illness is an autoimmune disease, where the body's immune system doesn't work properly and starts attacking normal intestinal cells. By removing these misguided immune cells and using stem cells to create healthy replacements, doctors hope to cure these diseases.


• Genetic diseases: In many genetic diseases, there is a specific defect in the genes. Stem cells that do not have this defect could be used to correct the problem. Type 1 diabetes, Parkinson's disease, and spinal cord injury are three conditions that Dominguez-Bendala says show the most promise in stem cell studies.

Stem Cell Experiments

Q: Have people already begun taking stem cells in experiments?

A: So far, few people have been experimentally treated with stem cells. In most cases, stem cells were used to treat patients who had very advanced diseases. More research on many more people will be needed before we have an idea of how well stem cells work.

In September 2006, European researchers reported promising results from clinical trials to test whether injections of bone marrow cells can repair heart attack damage.

Some scientists think bone marrow cells contain stem cells, but that hasn't been proven yet.

Q: Are stem cell treatments going to be safe?

A: This is a very important question, and there are no good answers at this point. If the stem cells came from another person, they could carry infections that that person has. This is a significant concern nowadays, particularly because of HIV/AIDS, but it is not likely to be a problem. Doctors already screen blood thoroughly for HIV and many other diseases, and they would definitely screen stem cells for things like HIV and other potential problems.

A bigger concern may be cancer. Most normal cells divide a certain number of times and then die. When cells are grown in the laboratory, as stem cells are, they can get "immortalized." That is, they can go on dividing endlessly -- similar to cancer cells. Immortalized cells are not cancer cells, but they are one step closer to cancer cells than normal cells. Thus, it is possible that they may someday form cancer.

Unfortunately, there is no way to know for sure without actually doing stem cell treatments. Doctors will be watching patients who receive stem cell treatments very closely, so if such a problem developed, they could treat it early.

"Safety is always the first priority. You don't want to cause anything that the patient didn't have before. So we are addressing those problems. We wouldn't go into clinical trials before doing that," Dominguez-Bendala says.

WebMD Medical News

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