Systemic Lupus Erythematosus (SLE)

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What is Systemic Lupus Erythematosus (SLE) and What Can You Do About It?

Learn about Systemic Lupus Erythematosus and self-help techniques.

Systemic Lupus Erythematosus and Autoimmunity 

Systemic Lupus Erythematosus is an autoimmune disease. The most common description of autoimmune disease is that it is a condition that occurs when the "body attacks itself". This definition doesn't even begin to encompass what autoimmunity really is. This disease is much more than inflammation caused by body "attacking itself".

The immune system, like most of the body, requires balance to function properly. T-helper 1 (Th1) cells and T-helper 2 cells (Th2) help regulate the body's response to foreign invaders.

Th1 uses white blood cells to go after viruses and cancer cells. Th2 immune cells use antibodies to go after bacteria.

Normally, the body strikes a balance by switching back and forth between Th1 and Th2. In a person with an autoimmune disorder, one dominates and suppresses the other.

Trans fats, mercury and other heavy metals, sugar and processed foods, alcohol, lack of sleep, lack of exercise, and stress are part of a modern lifestyle that can disrupt the Th1/Th2 balance.

Autoimmune Disease and Women

Th1 dominance in women is associated with autoimmunity and recurrent miscarriage in the first trimester of pregnancy. Additionally, children in the autism spectrum tend to be Th1 dominant.

Besides autoimmunity, Th2 dominance is characterized by a tendency toward allergies, frequent colds and viral infections, and cancer.

Both Th1 and Th2 cells make a protein substance known as cytokines. Cytokines cause inflammation.

Cytokines are a necessary part of our immunity. Inflammation should be a temporary response to injury or infection. It is the over-production (too many) of certain small cytokine molecules that leads to the invasion and inflammation of an organ or body system.

Changes in the Brain

In the brain, cytokines can cause behavioral changes. They can either prompt or worsen depression, anxiety, or anorexia. They may cause a person to become withdrawn.

Cytokines create fatigue and interfere with sleep patterns. They are one thing responsible for what has been termed "brain fog."

Autoimmune conditions are named or categorized according to where in the body cytokines are being overproduced and how the disease manifests itself.

For example, an overproduction of these cytokines in the joints causing pain and swelling is called Rheumatoid Arthritis (RA). It may go by different names and occur in different places in the body, but ultimately, autoimmunity is one disease with many different faces.

Important Note

DOZENS of prescription drugs are known to cause lupus.

Where Do Cytokines Attack in Lupus? 

Lupus can affect the skin, lungs,kidneys, heart,joints, and/or nervous system. Systemic Lupus Erythematosus (SLE) involves the internal organs. When only the skin is effected, the condition is called Discoid Lupus. Eventually, 5%-10% of individuals diagnosed with Discoid Lupus will also develop Systemic Lupus Erythematosus.

Symptoms of Systemic Lupus Erythematosus (SLE) 

Symptoms vary and can be mild or severe. They can also change from day to day.

-Almost all people with Systemic Lupus Erythematosus have joint pain and will eventually also develop arthritis.

-About half of those with Systemic Lupus Erythematosus develop a "butterfly" rash over the bridge of the nose and cheeks.

-Rash all over the body.

-Skin lesions

-pregnancy loss

-nephritis (kidney inflammation)

-kidney failure

-Up to 85% of those with Systemic Lupus Erythematosus develop some type of blood disorder.

-blood clots

-strokes

-pulmonary embolism

-Anemia

-Pericarditis

-Endocarditis

-Myocarditis

-Chest pain

-Arrhythmias

-Pleurisy (inflammation of the lining of the lung)

-Shortness of breath

-Up to 25% of those with Systemic Lupus Erythematosus develop neurologic disorders.

-Seizures

-Psychosis

-Headaches

Who Gets Lupus?

Anyone can be effected by lupus, but African Americans and Asians are hit the hardest.

Lupus also attacks 9 times as many women as men.

Lupus and Genetics 

A Natural Occurance

What you may or may not realize is that autoimmunity occurs naturally in everyone to some degree. In an ideal environment, the cells that are capable of attacking the body's own tissue are kept under control by the body itself.

If the body's environment falls out of balance, it can cause dsyfunction and breakdown of its internal safety mechanisms; causing the body to mistake itself as an enemy.

Just as your genetic make-up can cause greater susceptibility to burning in the sun, your genes can make you more susceptible to autoimmunity. However, genetics do not guarantee that you will develop any type of autoimmune disease.

According to the researchers at the University of Utah, genetics aren't everything. In the case of identical twins, when one twin develops Multiple Sclerosis, there is only a 30% chance of the other (genetically identical) twin also being diagnosed with the disease. A separate study showed the incidence of lupus between identical twins even lower at 24%. With Rheumatoid Arthritis, there is a 1 in 4 chance.

Learn About Nutrition and Autoimmune Diseases Like Systemic Lupus Erythematosus 

Your diet plays a major role in activating or suppressing cytokines that cause autoimmune inflammation. I can't stress this enough. Just about anything you put into your mouth will have a negative or positive consequence on your autoimmune condition.

It is as if everything that you swallow is sending a signal to your immune system to either cause more cytokines or less.

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Adhocreporter wrote

Hey heres a great lupus Diet website http://www.healing-lupus.com/lupus-diet-nutrition.html

Reply Posted May 21, 2008

by Heidi_Whitaker

I am a busy homeschool mom of 5 kids. I am also an author on the subject of autoimmunity.

I think I may now be addicted to Squidoo and enjoy squeezi... (more)

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