Three new eczema genes discovered

Eczema affects up to one in five children in the UK and other developed countries, with eight out of 10 cases occurring before a child reaches age five. Most children undergo remission in early adolescence, but up to 50% may have recurrences in adulthood. 60% of children who have a parent with eczema also have the condition, rising to 80% when both parents have it.

Eczema is commonly associated with food allergy, hay fever, asthma and a range of other diseases.

Speaking about the findings, lead author, Dr Lavinia Paternoster, from the University of Bristol, said: 'Eczema has lagged behind other common diseases, in terms of the number of genes discovered that predispose us to the condition. Our study is, to date, the largest study in eczema that attempts to identify which genes play a role. There is still a lot of work to do, but these findings indicate which biological mechanisms are important in this condition and are an important step towards improving diagnosis, management and treatment for eczema sufferers.'

Lead senior author and dermatologist, Professor Stephan Weidinger from the University of Kiel, Germany, added: 'Two disease genes that we found have never been associated with atopic dermatitis until now, while one has been implicated in asthma, reflecting the close relationship between the two diseases. Our findings will not immediately lead to genetic tests to predict who will develop eczema or to new ways of treatment, but they are an important step forward in this context.'

The research was carried out on around 10 000 cases and 40 000 controls from population-based studies in the UK, Europe, Australia and North America to identify genetic variants from across the entire genome that were associated with eczema.

Thus, this is the largest study of its kind on the genetics of eczema to date.

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