Vitamin B12
Could It Be B12?:
An Epidemic of Misdiagnoses
This crippler is a master of masquerade, striking different people in different ways. It afflicts one person with tremors, makes another depressed or psychotic, and causes agonizing leg and arm pains or paralysis in still another. It can mimic Alzheimer's disease, multiple sclerosis, early Parkinson's disease, diabetic neuropathy, or chronic fatigue syndrome. It can make men or women infertile or cause developmental disabilities in their children. Other times it lurks silently, stealthily increasing its victim's risk of deadly diseases ranging from stroke and heart attacks to cancer.
This medical disorder stems from a vitamin deficiency, but your standard multivitamin pill won't prevent it in many cases, and even high-dose oral formulas of this vitamin may not help. It's considered an "old people's disease" by doctors, but it can strike any person at any age, and it sometimes hits children the hardest.
The disorder is vitamin B12 deficiency. If you develop this deficiency it's easy to spot, easy to treat, and easy to cure--but only if your doctor diagnoses you before it's too late. Unfortunately, that frequently doesn't happen.
This isn't a new or fad disease. In fact, you'll find it listed in the textbooks of any first-year medical student. It's not a rare disease, either: If you're over forty, you're at an elevated risk for dangerous B12 deficiency, and if you're over sixty, you have up to a 40 percent chance of having dangerously low B12 levels.
What do these people have in common?
* A 40-year old Washington Post reporter who loses his ability to write, falls when he attempts to walk, and becomes so confused that his wife suspects early-onset Alzheimer's.
* A beautiful, normal eight-month-old baby who gradually loses her speech, stops responding to her parents, and eventually can't even sit up by herself.
* A 20-year-old woman who becomes severely depressed and attempts to kill herself.
* A ballet dancer who undergoes cosmetic surgery and ends up nearly unable to walk.
* A 35-year-old man who starts wetting himself and can no longer walk steadily or grip with his hands.
* An 86-year-old man who becomes delusional and kills his wife.
* A 54-year-old woman experiencing paranoid delusions and violent outbursts, coupled with symptoms her doctor diagnoses as multiple sclerosis.
* A four-year-old boy diagnosed with autism.
* A 73-year-old whose doctors attribute his repeated falls to "mini-strokes."
* A young woman unable to conceive.
* A grandfather transformed, in less than a year, from a healthy jogger to a depressed, confused man diagnosed with senile dementia.
Here's what these patients don't have in common: a correct diagnosis. Instead they have a plethora of incorrect, often hopeless diagnoses: mental retardation, autism, multiple sclerosis, psychosis, senile dementia, transient ischemic attacks, depression, diabetic neuropathy. But, in reality, they all suffer from the same medical condition: vitamin B12 deficiency.
The Author, Sally Pacholok, R.N., BSN, is an emergency room nurse with eighteen years of experience. She received her bachelor's degree in nursing from Wayne State University. Prior to entering the field of nursing, she received an Associate's Degree of Applied Science with magna cum laude honors. She is also an Advanced Emergency Medical Technician (A-EMT), and worked as a paramedic prior to and during nursing school. She has worked in health care for a total of twenty-five years, and has cared for thousands of patients. In addition, she is an Advanced Cardiac Life Support (ACLS) provider, and has assisted instructors at a local community college in training paramedics in ACLS. She is a Trauma Nursing Core Course (TNCC) Provider, an Emergency Nurse Pediatric Course (ENPC) Provider, and a member of the Emergency Nurses Association (ENA). In 1985, Pacholok diagnosed herself with vitamin B12 deficiency, after her doctors had failed to identify her condition. As a result, she is passionate about the need to educate the public about the dangerous consequences of this hidden and all-too-common disease. Jeffrey J. Stuart, D.O., a physician who has practiced emergency medicine for twelve years, is board certified in this field. He is also certified in Advanced Trauma Life Support, Advanced Cardiac Life Support (ACLS), Advanced Pediatric Life Support, and Neonatal Resuscitation. Stuart received his Doctor of Osteopathy degree from the Chicago College of Osteopathic Medicine. His training includes field amputation and hazardous materials decontamination, and he has also participated in training sessions with the Detroit Metropolitan Airport SWAT team. Dr. Stuart participated in visual brain research at the National Institute of Mental Health in Bethesda, Maryland, in 1987, and was involved in cholesterol metabolism research at the Rockefeller University Hospital in New York City in 1985. He is a member of the American Osteopathic Association, the American College of Osteopathic Emergency Physicians.
Could It Be B12?: An Epidemic of Misdiagnoses
Excellent handbook on B12
Before the availability of the internet for easier research, I never found a good explanation of the workings of B12 in the body (for non-medically-trained people to understand). Most of the physicians I encountered had no good working knowledge of Pernicious Anemia.
This book is an excellent reference for how B12 works, why it is essential that it be absorbed properly, and a long list of other considerations, including possible serious wrong diagnoses, in which B12 mal-absorption should be examined.
Other reviewers have pointed out the readability, devotion to accuracy, and the helpful tone of this useful book. If you or a loved one has any condition related to B12, I think you will be glad to read this book. For some of us, this knowledge will make the difference between a healthy life and a miserable one. - Blue Willow (Tokyo, Japan)
Excellent resource regarding B12 deficiency
Recently I was diagnosed with B12 deficiency, after struggling with anemia, exhaustion, and a decreased immune system for much of my 20's. I can hardly believe what a difference B12 shots have made in my life. I'm half Scandinavian, and at least one of my Norwegian cousins has this deficiency, too, which can run in families. I have been researching everything I could find on B12 deficiency. Sally Pacholok, RN, and her husband, Jeffery Stuart, DO, have written a well-researched book on the symptoms, diagnostic tests, and treatment for B12. I wish the book dealt a little more with some of the recovery process, but the book is very thorough and well-researched.
The 13 chapters are as follows:
1. An Invisible Epidemic
2. Is It Aging--or Is It B12 Deficiency?
3. Deadly Mimic: When B12 Deficiency Masquerades as Multiple Sclerosis or Other Neurological Disorders
4. Am I Losing My Mind? When B12 Deficiency Causes Mental Illness
5. Stroke, Heart Disease, and Other Vascular Problems: The B12-Homocysteine Connection
6. Lost Children: When B12 Deficiency Causes Developmental Disabilities or Learning Problems
7. Vitamin B12 and Cancer, Impaired Immune Function, and Autoimmune Disease
8. Under the Knife: Why Low B12 Levels Make Surgery Dangerous
9. Can't Conceive? How B12 Deficiency Contributes to Male and Female Infertility
10. Protecting Yourself: Are You at Risk for Vitamin B12 Deficiency?
11. Information for Physicians
12. Speculation: The Possible Role of Vitamin B12 in Autism
13. A Call for a United Effort
This book is well-written, interspersing case studies/stories with research, and is a fairly easy read. If you have B12 deficiency, or have family or patients with B12 deficiency, this book is highly recommended. - annesailorgirl "annesailorgirl" (Berrien Spgs, MI USA)
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Vitamin B12
Vitamin B12 is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is one of the eight B vitamins. It is normally involved in the metabolism of every cell of the body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis and energy production.
Vitamin B12 is the name for a class of chemically-related compounds, all of which have vitamin activity. It is structurally the most complicated vitamin and it contains the biochemically rare element cobalt. Biosynthesis of the basic structure of the vitamin can only be accomplished by bacteria, but conversion between different forms of the vitamin can be accomplished in the human body. A common synthetic form of the vitamin, cyanocobalamin, does not occur in nature, but is used in many pharmaceuticals, supplements and as food additive, due to its stability and lower cost. In the body it is converted to the physiological forms, methylcobalamin and adenosylcobalamin, leaving behind the cyanide, albeit in minimal concentration. More recently, hydroxocobalamin, methylcobalamin and, adenosylcobalamin can also be found in more expensive pharmacological products and food supplements. The utility of these is presently debated.
Historically, vitamin B12 was discovered from its relationship to the disease pernicious anemia, which is an autoimmune disease that destroys parietal cells in the stomach that secrete intrinsic factor. Intrinsic factor is crucial for the normal absorption of B12, therefore, a lack of intrinsic factor, as seen in pernicious anemia, causes a vitamin B12 deficiency. Many other subtler kinds of vitamin B12 deficiency, and their biochemical effects, have since been elucidated.
Books about Vitamin B12
7 reasons to aim for more Vitamin B12 than you're probably getting now.(Just In): An article from: Environmental Nutrition
Release Date: 05/26/2009
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Studies in the Metabolism of Vitamin B12
Release Date: 01/01/1965
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The 2009-2014 Outlook for Vitamin B12 Oral Hematinics in Greater China
Release Date: 01/08/2009
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