Vitamin B6
The Homocysteine Revolution - Vitamin B6 and B12 !!!
Essential reading for those wishing to prevent heart disease
What medical dogma has overlooked until quite recently is that plaque builds up only in arteries that have been wounded in some fashion. Arterial plaque is, in essence a form of scab that forms on wounded arteries to protect us from internal hemorrhaging. What causes wounded arteries? One cause is free radicals, which can be combatted by antioxidants.
But a second major cause of arterial wounding -- and arterial plaque -- was discovered by the author of this book, Dr. Kilmer McCully: elevated concentrations in the blood of a chemical called homocysteine. Homocysteine is a natural product of the metabolism af an amino acid called methionine and, therefore, our body's always contain some homocysteine.
Vitamins B6, B12, and folic acid keep blood concentrations of homocysteine low enough to be safe.
But deficiency of these vitamins can allow homocysteine to build up to concentrations that can wound our arteries and lead to the formation of arterial plaque -- which can eventually trigger a heart attack. Recent research has confirmed Dr. McCully's findings. If you want to understand the role of homocysteine in causing cardiovascular disease and resultant heart attacks -- and learn how to protect yourself from them -- I strongly suggest that you acquire and read this valuable book. - D. R Schryer (Hampton, VA United States)
The Homocysteine Revolution
Good intro to Homocysteine
Good book. I knew nothing about homocysteine when I started it, except that it was a marker for inflammation in the body, but I finished with a clear idea of its role in arteriosclerosis and general health. It's written from a historical point of view, both the more distant history of the first developments in understanding, and the last 30-35 years, when the author played a significant part. At first I did not like this indirect approach, wanting just the science, but it did turn out to be an interesting read and not a bad way to communicate the information. For a lay-reader, I found it stayed within the bounds of comprehensibility, but you do end up with maybe a dozen or so different biochemicals flitting in and out of the text, often with names that are slight variants on each other. But overall it's clear.
I'm surprised at the reviewer who thought there was no advice for personal health - that's the whole topic of chapter 5. I felt I got a clear picture about how to apply the information for personal health. Proponents of the paleolithic diet will find one of McCully's final conclusions about diet (to eat little meat and fish) indefensible. But that's a quibble in the book as a whole, and don't let it put you off the book if you want a good layman's introduction to homocysteine and how it relates to health. - Paul (Boston MA)
Amazon Price: $11.53 (as of 12/20/2009) ![]()
List Price: $16.95
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Vitamin B6
Vitamin B6 is a water-soluble vitamin and is part of the vitamin B complex group. Pyridoxal phosphate (PLP) is the active form and is a cofactor in many reactions of amino acid metabolism, including transamination, deamination, and decarboxylation. PLP also is necessary for the enzymatic reaction governing the release of glucose from glycogen.
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